Purpose—Much has transpired since the last scientific statement on pediatric stroke was
published 10 years ago. Although stroke has long been recognized as an adult health …

We conducted systematic reviews of predefined clinical questions and used the Grading of
Recommendations, Assessment, Development and Evaluations approach to develop …

A. Children and adolescents 1. Type 1 diabetes Glycemic control a. Screening and
management of chronic complications in children and adolescents with type 1 diabetes i …

Cardiovascular diseases are a leading cause of morbidity and mortality in most developed
countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to …

Inhibitors selective for prostaglandin G/H synthase-2 (PGHS-2)(known colloquially as COX-
2) were designed to minimize gastrointestinal complications of traditional NSAIDs—adverse …

The burden of cardiovascular disease (CVD) among patients with diabetes is substantial.
Individuals with diabetes are at two-to fourfold increased risk of cardiovascular events …

Acetylsalicylic acid (aspirin) is a prototypic cyclooxygenase (COX) inhibitor. It was
synthesized serendipitously from a natural compound, ie, salicylic acid, with known …

Obesity is associated with increased cardiovascular disease. Metabolic syndrome (MS)
identifies substantial additional cardiovascular risk beyond the individual risk factors, and is …

The clinical pharmacology of antiplatelet drugs has been reviewed previously by the
European Society of Cardiology (ESC) Task force and by the 8th American College of Chest …

During the past 30 years, several developments have occurred in the antiplatelet field,
including the role of aspirin in primary prevention of atherosclerotic cardiovascular disease …