This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

This report is the continuation of two earlier reports that defined human arterial intima and
precursors of advanced atherosclerotic lesions in humans. This report describes the …

Cardiovascular pathologies maintain the leading position in mortality worldwide.
Atherosclerosis is a chronic disease that can result in a variety of serious complications …

The compositions of lesion types that precede and that may initiate the development of
advanced atherosclerotic lesions are described and the possible mechanisms of their …

Evidence to support an important role of oxidative modification in mediating the
atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox …

Background The oxidative modification of low-density lipoproteins increases their
incorporation into the arterial intima, an essential step in atherogenesis. Although dietary …

Background Interest in the antioxidant vitamin E as a possible protective nutrient against
coronary disease has intensified with the recognition that oxidized low-density lipoprotein …

Examines the relationship between the increase in plasma cholesterol and the risk of clinical
coronary artery disease (CAD). Importance of the oxidative modification of low-density …

The importance of estrogens in homeostatic regulation of many cellular and biochemical
events is well illustrated by the pathophysiologic changes that occur with estrogen …

Many recent studies have implicated dietary factors in the cause and prevention of important
diseases, including cancer, coronary heart disease, birth defects, and cataracts. There is …