Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

The term osteoimmunology was coined many years ago to describe the research field that
deals with the cross-regulation between bone cells and the immune system. As a matter of …

The physiology of B cells is intimately connected with the function of their B‐cell receptor
(BCR). B‐cell lymphomas frequently (dys) regulate BCR signalling and thus take advantage …

Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase
important in B‐lymphocyte development, differentiation, and signaling. Btk is a member of …

Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR)
signals to make crucial cell-fate decisions at several checkpoints during their development …

Osteoclasts are unique, multinucleated giant cells that decalcify and degrade the bone
matrix. They originate from hematopoietic cells and their differentiation is dependent on a …

Sophisticated genetic tools have made possible the identification of the genes responsible
for most well-described immunodeficiencies in the past 15 years. Mutations in Btk …

Chronic graft-versus-host disease (cGVHD) is a life-threatening impediment to allogeneic
hematopoietic stem cell transplantation, and current therapies do not completely prevent …