Transformed cells must acquire specific characteristics to be malignant. Weinberg and
Hanahan characterize these characteristics as cancer hallmarks. Though these features are …

Natural antisense transcripts (NATs), which are transcribed from opposite strands of DNA
with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to …

Replicative immortality is a hallmark of cancer cells governed by telomere maintenance.
Approximately 90% of human cancers maintain their telomeres by activating telomerase …

The spatial partitioning of the transcriptome in the cell is an important form of gene-
expression regulation. Here, we address how intron retention influences the spatio-temporal …

Objective To investigate the role of lncRNA-BLACAT1 in promoting H3K27 trimethylation of
CDKN1C gene by recruiting EZH2 to regulate CCNE on glycolysis and mitochondrial …

Telomeres, protective DNA-protein complexes at the end of eukaryotic linear chromosomes,
play pivotal roles in the maintenance of genomic stability during cell division. When …

Telomerase, an RNA-dependent DNA polymerase synthesizing telomeric TTAGGG
sequences, is primarily silent in normal human urothelial cells (NHUCs), but widely activated …

Antisense long noncoding RNA (as-lncRNA) is a lncRNA transcribed in reverse orientation
that is partially or completely complementary to the corresponding sense protein-coding or …

In-depth analysis of global RNA sequencing has enabled a comprehensive overview of
cellular transcriptomes and revealed the pervasive transcription of divergent RNAs from …

Despite advances in cervical cancer screening and human papilloma virus (HPV) vaccines,
cervical cancer remains a global health burden. The standard treatment of cervical cancer …