Age-related macular degeneration (AMD) is a chronic and progressive degenerative
disease of the retina, which culminates in blindness and affects mainly the elderly …

Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …

The complement system is an essential element of the innate immune response that
becomes activated upon recognition of molecular patterns associated with microorganisms …

Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

The retina provides exquisitely sensitive vision that relies on the integrity of a uniquely
vulnerable cell, the photoreceptor (PR). The genetic and mechanistic causes of retinal …

The factor H (FH) protein family is emerging as a complex network of proteins controlling the
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …

Nuclear Magnetic Resonance (NMR) has been widely employed to assess diverse features
of glycan–protein molecular recognition events. Different types of qualitative and quantitative …

The serum protein complement factor H (FH) ensures downregulation of the complement
alternative pathway, a branch of innate immunity, upon interaction with specific glycans on …

The complement cascade is an ancient immune‐surveillance system that not only provides
protection from pathogen invasion but has also evolved to participate in physiological …