Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by
compulsive overconsumption of rewarding substances such as substance abuse, binge …

The role of glucagon-like peptide 1 (GLP-1) in insulin-dependent signaling is well-known;
GLP-1 enhances glucose-dependent insulin secretion and lowers blood glucose in …

The peripheral peptide hormone ghrelin is a powerful stimulator of food intake, which leads
to body weight gain and adiposity in both rodents and humans. The hormone, thus …

The selective 5-HT2C receptor agonist lorcaserin, in conjunction with lifestyle modification,
was approved by the FDA in 2012 for weight management. It has been marketed in the US …

Eating behaviors are influenced by the reinforcing properties of foods that can favor
decisions driven by reward incentives over metabolic needs. These food reward-motivated …

The growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor
(GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is …

The number of people living with obesity has tripled worldwide since 1975 with serious
implications for public health, as obesity is linked to a significantly higher chance of early …

Aims The incidence of obesity increases annually. It is closely related to the occurrence of
cardiovascular diseases, malignant tumors, etc., and has become a major global health …

Approximately 14.4 million Americans are experiencing alcohol use disorder (AUD) and
about two-thirds of people who experience drug addiction will relapse, highlighting the need …

Anorexia nervosa (AN) is the psychiatric disorder with the highest mortality rate; however,
the mechanisms responsible for its pathogenesis remain largely unknown. Large-scale …