Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
Dynamic clamp in electrophysiological studies on stem cell–derived cardiomyocytes—Why and how?
AO Verkerk, R Wilders - Journal of Cardiovascular Pharmacology, 2021 - journals.lww.com
Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) are supposed to be a
good human-based model, with virtually unlimited cell source, for studies on mechanisms …
good human-based model, with virtually unlimited cell source, for studies on mechanisms …
Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly
used for personalised medicine and preclinical cardiotoxicity testing. Reports on hiPSC-CM …
used for personalised medicine and preclinical cardiotoxicity testing. Reports on hiPSC-CM …
[PDF][PDF] An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic proarrhythmia mechanisms
Tuesday, February 22, 2022 303a previously unidentified funny current (If) block by quinine,
which we confirmed with experiments using a HEK-293 expression line and automated …
which we confirmed with experiments using a HEK-293 expression line and automated …
Injection of IK1 through dynamic clamp can make all the difference in patch-clamp studies on hiPSC-derived cardiomyocytes
AO Verkerk, R Wilders - Frontiers in physiology, 2023 - frontiersin.org
Human-induced stem cell-derived cardiomyocytes (hiPSC-CMs) are a valuable tool for
studying development, pharmacology, and (inherited) arrhythmias. Unfortunately, hiPSC …
studying development, pharmacology, and (inherited) arrhythmias. Unfortunately, hiPSC …
Modelling the interaction between stem cells derived cardiomyocytes patches and host myocardium to aid non-arrhythmic engineered heart tissue design
Application of epicardial patches constructed from human-induced pluripotent stem cell-
derived cardiomyocytes (hiPSC-CMs) has been proposed as a long-term therapy to treat …
derived cardiomyocytes (hiPSC-CMs) has been proposed as a long-term therapy to treat …
A deep learning algorithm to translate and classify cardiac electrophysiology
The development of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) has
been a critical in vitro advance in the study of patient-specific physiology, pathophysiology …
been a critical in vitro advance in the study of patient-specific physiology, pathophysiology …
Investigation of the effects of the short QT syndrome D172N Kir2. 1 mutation on ventricular action potential profile using dynamic clamp
C Du, RL Rasmusson, GC Bett, B Franks… - Frontiers in …, 2022 - frontiersin.org
The congenital short QT syndrome (SQTS) is a cardiac condition that leads to abbreviated
ventricular repolarization and an increased susceptibility to arrhythmia and sudden death …
ventricular repolarization and an increased susceptibility to arrhythmia and sudden death …
A dynamic clam** approach using in silico IK1 current for discrimination of chamber-specific hiPSC-derived cardiomyocytes
Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CM) constitute a
mixed population of ventricular-, atrial-, nodal-like cells, limiting the reliability for studying …
mixed population of ventricular-, atrial-, nodal-like cells, limiting the reliability for studying …
Ultrarapid Delayed Rectifier K+ Channelopathies in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
S Hilderink, HD Devalla, L Bosch, R Wilders… - Frontiers in cell and …, 2020 - frontiersin.org
Atrial fibrillation (AF) is the most common cardiac arrhythmia. About 5–15% of AF patients
have a mutation in a cardiac gene, including mutations in KCNA5, encoding the Kv1. 5 α …
have a mutation in a cardiac gene, including mutations in KCNA5, encoding the Kv1. 5 α …