Systemic lupus erythematosus (SLE) is a typical autoimmune disease with a complex
pathogenesis and genetic predisposition. With continued understanding of this disease, it …

SLE is an autoimmune inflammatory disease in which various pro‐and anti‐inflammatory
cytokines, including TGF‐β, IL‐10, BAFF, IL‐6, IFN‐α, IFN‐γ, IL‐17, and IL‐23, play crucial …

Spontaneously developed germinal centers (GCs [Spt-GCs]) harbor autoreactive B cells that
generate somatically mutated and class-switched pathogenic autoantibodies (auto-Abs) to …

Overactivity of the germinal center (GC) pathway resulting from accumulation of follicular
helper T (Tfh) cells causes autoimmunity, underscoring the need to understand the factors …

Significant advances in the understanding of the molecular basis of innate immunity have
led to the identification of interferons (IFNs), particularly IFN-α, as central mediators in the …

Immunoglobulin-A vasculitis (IgAV) is classically a childhood small-sized blood vessel
vasculitis with predominant involvement of the skin. Gastrointestinal and joint manifestations …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
breakdown of immune tolerance leading to excessive inflammation and tissue damage …

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease involving
most immune cells. Studies in both experimental animal models of lupus and patients with …

Objectives Genetic variants in the transcription factor STAT4 are associated with increased
susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype …

Background A minority of patients with advanced non-small-cell lung cancer (NSCLC)
benefit from treatment with immune checkpoint inhibitors (ICIs). Ineffective effector function of …