The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Summary Ultra-slow,∼ 0.1-Hz variations in the oxygenation level of brain blood are widely
used as an fMRI-based surrogate of" resting-state" neuronal activity. The temporal …

The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …

To understand how arousal state impacts cerebral hemodynamics and neurovascular
coupling, we monitored neural activity, behavior, and hemodynamic signals in un …

Neurovascular coupling (NVC), which mediates rapid increases in cerebral blood flow in
response to neuronal activation, is commonly used to map brain activation or dysfunction …

Aging is frequently associated with compromised cerebrovasculature and pericytes.
However, we do not know how normal aging differentially impacts vascular structure and …

Consciousness is lost within seconds upon cessation of cerebral blood flow. The brain
cannot store oxygen, and interruption of oxidative phosphorylation is fatal within minutes …

The movement of fluid into, through, and out of the brain plays an important role in clearing
metabolic waste. However, there is controversy regarding the mechanisms driving fluid …