The conserved mesencephalic astrocyte-derived neurotrophic factor (MANF) is known for
protecting dopaminergic neurons and functioning in various other tissues. Previously, we …

Senescent cells compromise tissue structure and function in older organisms. We recently
identified senescent fibroadipogenic progenitors (FAPs) with activated chemokine signaling …

Background Sarcopenia is a condition characterized by the age-related loss of skeletal
muscle mass and function. The pathogenesis of the disease is influenced by chronic low …

Aging causes degenerative changes in organs, leading to a decline in physical function.
Over the past two decades, researchers have made significant progress in understanding …

Background Although pharmacological effects of SGLT2 inhibitors on the development of
frailty and sarcopenia were known, the role of SGLT1 remained less clear. The present study …

Facioscapulohumeral muscular dystrophy (FSHD) is a progressive myopathy caused by the
aberrant increased expression of the DUX4 retrogene in skeletal muscle cells. The DUX4 …

Excessive alcohol exposure can cause neurobehavioral deficits and structural alterations in
the brain. Emerging research evidence suggests that endoplasmic reticulum (ER) stress …

Muscle regeneration is impaired in the aged organism, due to both intrinsic defects of
muscle stem cells (MuSCs) and alterations of their environmental niche. However, the latter …

Skeletal muscle regeneration depends on the function of fibro/adipogenic progenitors
(FAPs). Here we show that aging impairs myogenic stem cells and immunomodulatory …

Age-related alterations in the immune system are starting to emerge as key contributors to
impairments found in aged organs. A decline in regenerative capacity is a hallmark of tissue …