Thymoquinone: A small molecule from nature with high therapeutic potential

S Malik, A Singh, P Negi, VK Kapoor - Drug Discovery Today, 2021 - Elsevier
Abstract Thymoquinone (TQ; 2-isopropyl-5-methylbenzo-1, 4-quinone), the main active
constituent of Nigella sativa, has been proven to have great therapeutic properties in …

Delivery of oxaliplatin to colorectal cancer cells by folate-targeted UiO-66-NH2

A Hashemzadeh, F Amerizadeh, F Asgharzadeh… - Toxicology and Applied …, 2021 - Elsevier
Oxaliplatin is being used in different malignancies and several side effects are reported for
patients taking Oxaliplatin, including peripheral neuropathy, nausea and vomiting, diarrhea …

Comprehensive and updated review on anti-oxidant effects of Nigella sativa and its constituent, thymoquinone, in various disorders

MR Aslani, S Saadat… - Iranian Journal of Basic …, 2024 - pmc.ncbi.nlm.nih.gov
Several pharmacological effects were described for Nigella sativa (N. sativa) seed and it has
been used traditionally to treat various diseases. In this review article, the updated and …

Thymoquinone protects against cardiac mitochondrial DNA loss, oxidative stress, inflammation and apoptosis in isoproterenol-induced myocardial infarction in rats

AA Khalifa, RM Rashad, WF El-Hadidy - Heliyon, 2021 - cell.com
Introduction Myocardial infarction (MI) is an ischemic life-threatening disease with
exaggerated oxidative stress state that vigorously damages the cardiomyocyte membrane …

Raspberry ketone attenuates hepatic Fibrogenesis and inflammation via regulating the crosstalk of FXR and PGC-1α signaling

YC Jiang, JY Dou, MY Xuan, C Gao, ZX Li… - Journal of Agricultural …, 2024 - ACS Publications
Hepatic fibrosis is a compensatory response to chronic liver injury and inflammation, and
dietary intervention is recommended as one of the fundamental prevention strategies …

[HTML][HTML] Thymoquinone-PLGA-PVA nanoparticles ameliorate bleomycin-induced pulmonary fibrosis in rats via regulation of inflammatory cytokines and iNOS …

SAM Saghir, NA Al-Gabri, AF Khafaga, NH El-Shaer… - Animals, 2019 - mdpi.com
Simple Summary In this study, we evaluated the role of thymoquinone-PLGA-PVA
nanoparticles (TQ-PLGA-PVA-NPs) in the amelioration of lung fibrosis induced …

[HTML][HTML] Anxiolytic and anti-inflammatory role of thymoquinone in arsenic-induced hippocampal toxicity in Wistar rats

F Firdaus, MF Zafeer, M Ahmad, M Afzal - Heliyon, 2018 - cell.com
Arsenic (As) is a widely existing metalloid in the biosphere. Drinking water contamination by
arsenic is a major route of human exposure, either by natural means or through industrial …

Thymoquinone protects thioacetamide‐induced chronic liver injury by inhibiting TGF‐β1/Smad3 axis in rats

S Raghunandhakumar, D Ezhilarasan… - … of Biochemical and …, 2024 - Wiley Online Library
Chronic liver injury due to various etiological factors results in excess secretion and
accumulation of extracellular matrix proteins, leading to scarring of liver tissue and ultimately …

[PDF][PDF] Studying the actions of sage and thymoquinone combination on metabolic syndrome induced by high-fat diet in rats.

SM Alanazi, RA Alsaqer, FI Alsaeed… - European Review for …, 2023 - europeanreview.org
Studying the actions of sage and thymoquinone combination on metabolic syndrome induced
by high-fat diet in rats Page 1 2404 Abstract. – OBJECTIVE: High-fat diet is one of the most …

Thymoquinone alleviates liver fibrosis via mir‐30a‐mediated epithelial‐mesenchymal transition

W Geng, C Li, Y Zhan, R Zhang… - Journal of cellular …, 2021 - Wiley Online Library
Thymoquinone (TQ), the main active constituent of Nigella sativa seeds, has been shown to
play a role in antioxidation, anti‐inflammation, and antitumor. Recent studies have …