The pathophysiology of glaucoma is complex, multifactorial and not completely understood.
Elevated intraocular pressure (IOP) and/or impaired retinal blood flow may cause initial optic …

The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly.
The mechanisms initiating glaucoma and driving neuronal vulnerability during normal aging …

Summary The apolipoprotein E4 (APOE4) allele is associated with an increased risk of
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …

Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the
precise roles are not known. Understanding these complex processes, which may also be a …

Background Glaucoma, the leading cause of irreversible blindness worldwide, is a type of
retinal disease characterized by the selective death of retinal ganglion cells (RGCs) …

Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …

Glaucoma is a complex neurodegenerative disease with many clinical subtypes. Some of its
rare forms include pigmentary glaucoma, uveitic glaucoma and congenital glaucoma. While …

Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve.
For several decades, we have understood that the RGC death process was executed by …

Intraocular pressure (IOP) is the critical risk factor for glaucoma, a neurodegenerative
disease and frequent cause of blindness worldwide. As of today, all effective strategies to …