Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

SE Arnold, Z Arvanitakis… - Nature Reviews …, 2018 - nature.com
Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

The bioavailability, transport, and bioactivity of dietary flavonoids: A review from a historical perspective

G Williamson, CD Kay, A Crozier - Comprehensive Reviews in …, 2018 - Wiley Online Library
Flavonoids are plant‐derived dietary components with a substantial impact on human
health. Research has expanded massively since it began in the 1930s, and the complex …

A nanozyme‐based artificial peroxisome ameliorates hyperuricemia and ischemic stroke

J **, R Zhang, L Wang, W Xu, Q Liang… - Advanced Functional …, 2021 - Wiley Online Library
Artificial peroxisome has drawn a lot of attentions for its usefulness in fabricating protocell
system and great potential in treating diseases. However, it is still a significant challenge to …

Superoxide dismutase administration: A review of proposed human uses

AC Rosa, D Corsi, N Cavi, N Bruni, F Dosio - Molecules, 2021 - mdpi.com
Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant
defense against oxidative stress in the body. SOD supplementation may therefore trigger the …

Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs

D Charvin, R Medori, RA Hauser… - Nature Reviews Drug …, 2018 - nature.com
Existing therapeutic strategies for managing Parkinson disease (PD), which focus on
addressing the loss of dopamine and dopaminergic function linked with degeneration of …

Targeting microglial activation states as a therapeutic avenue in Parkinson's disease

SR Subramaniam, HJ Federoff - Frontiers in aging neuroscience, 2017 - frontiersin.org
Parkinson's disease (PD) is a chronic and progressive disorder characterized
neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular …

Treatment strategies against diabetes: Success so far and challenges ahead

R Khursheed, SK Singh, S Wadhwa, B Kapoor… - European journal of …, 2019 - Elsevier
The growing disease burden of diabetes mellitus is an important public health concern,
affecting over 400 million people globally. This epidemic, if not controlled in time, leads to …

Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease

BS Thawkar, G Kaur - Journal of neuroimmunology, 2019 - Elsevier
Microglial activation is a distinguished attribute in many neurodegenerative diseases of
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …

PPARs as nuclear receptors for nutrient and energy metabolism

F Hong, S Pan, Y Guo, P Xu, Y Zhai - Molecules, 2019 - mdpi.com
It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs)
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …

Significant roles of neuroinflammation in Parkinson's disease: therapeutic targets for PD prevention

Y Lee, S Lee, SC Chang, J Lee - Archives of pharmacal research, 2019 - Springer
Glial cells outnumber neurons in the brain and play important roles in the neuroinflammation
that accompanies brain damage in neurodegenerative diseases. In Parkinson's disease …