Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
SE Arnold, Z Arvanitakis… - Nature Reviews …, 2018 - nature.com
Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …
The bioavailability, transport, and bioactivity of dietary flavonoids: A review from a historical perspective
Flavonoids are plant‐derived dietary components with a substantial impact on human
health. Research has expanded massively since it began in the 1930s, and the complex …
health. Research has expanded massively since it began in the 1930s, and the complex …
A nanozyme‐based artificial peroxisome ameliorates hyperuricemia and ischemic stroke
Artificial peroxisome has drawn a lot of attentions for its usefulness in fabricating protocell
system and great potential in treating diseases. However, it is still a significant challenge to …
system and great potential in treating diseases. However, it is still a significant challenge to …
Superoxide dismutase administration: A review of proposed human uses
AC Rosa, D Corsi, N Cavi, N Bruni, F Dosio - Molecules, 2021 - mdpi.com
Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant
defense against oxidative stress in the body. SOD supplementation may therefore trigger the …
defense against oxidative stress in the body. SOD supplementation may therefore trigger the …
Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs
Existing therapeutic strategies for managing Parkinson disease (PD), which focus on
addressing the loss of dopamine and dopaminergic function linked with degeneration of …
addressing the loss of dopamine and dopaminergic function linked with degeneration of …
Targeting microglial activation states as a therapeutic avenue in Parkinson's disease
SR Subramaniam, HJ Federoff - Frontiers in aging neuroscience, 2017 - frontiersin.org
Parkinson's disease (PD) is a chronic and progressive disorder characterized
neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular …
neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular …
Treatment strategies against diabetes: Success so far and challenges ahead
The growing disease burden of diabetes mellitus is an important public health concern,
affecting over 400 million people globally. This epidemic, if not controlled in time, leads to …
affecting over 400 million people globally. This epidemic, if not controlled in time, leads to …
Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease
Microglial activation is a distinguished attribute in many neurodegenerative diseases of
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …
PPARs as nuclear receptors for nutrient and energy metabolism
F Hong, S Pan, Y Guo, P Xu, Y Zhai - Molecules, 2019 - mdpi.com
It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs)
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …
Significant roles of neuroinflammation in Parkinson's disease: therapeutic targets for PD prevention
Glial cells outnumber neurons in the brain and play important roles in the neuroinflammation
that accompanies brain damage in neurodegenerative diseases. In Parkinson's disease …
that accompanies brain damage in neurodegenerative diseases. In Parkinson's disease …