X-ray crystallography has been central to the development of many fields of science over the
past century. It has now matured to a point that as long as good-quality crystals are …

Macromolecular crystallography at synchrotron sources has proven to be the most influential
method within structural biology, producing thousands of structures since its inception. While …

Structure determination of proteins and other macromolecules has historically required the
growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding …

For centuries, physical imaging tools have been opening new frontiers in biology. The
discovery of the cell nucleus by Scottish botanist Robert Brown was made possible by early …

Photosynthesis, a process catalysed by plants, algae and cyanobacteria converts sunlight to
energy thus sustaining all higher life on Earth. Two large membrane protein complexes …

MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory
cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms …

X-ray free-electron lasers have opened up the possibility of structure determination of
protein crystals at room temperature, free of radiation damage. The femtosecond-duration …

This paper presents development of an X-ray pixel detector with a multi-port charge-coupled
device (MPCCD) for X-ray Free-Electron laser experiments. The fabrication process of the …

A new approach for collecting data from many hundreds of thousands of microcrystals using
X-ray pulses from a free-electron laser has recently been developed. Referred to as serial …

Structural rearrangements within single molecules occur on ultrafast time scales. Many
aspects of molecular dynamics, such as the energy flow through excited states, have been …