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Recent metabolomic developments for antimalarial drug discovery
Malaria is a parasitic disease that remains a global health issue, responsible for a significant
death and morbidity toll. Various factors have impacted the use and delayed the …
death and morbidity toll. Various factors have impacted the use and delayed the …
Identification of promising inhibitors for Plasmodium haemoglobinase Falcipain-2, using virtual screening, molecular docking, and MD Simulation
Abstract Background Falcipain-2 (FP-2), the major haemoglobinase of the human malaria
parasite Plasmodium falciparum is currently gaining clinical significance as a drug target of …
parasite Plasmodium falciparum is currently gaining clinical significance as a drug target of …
Recent advances in system based study for anti-malarial drug development process
Background: Presently, malaria is one of the most prevalent and deadly infectious disease
across Africa, Asia, and America that has now started to spread in Europe. Despite large …
across Africa, Asia, and America that has now started to spread in Europe. Despite large …
Machine learning methods for predicting essential metabolic genes from Plasmodium falciparum genome-scale metabolic network
Essential genes are those whose presence is vital for a cell's survival and growth. Detecting
these genes in disease-causing organisms is critical for various biological studies, including …
these genes in disease-causing organisms is critical for various biological studies, including …
Combination of computational techniques and RNAi reveal targets in Anopheles gambiae for malaria vector control
Increasing reports of insecticide resistance continue to hamper the gains of vector control
strategies in curbing malaria transmission. This makes identifying new insecticide targets or …
strategies in curbing malaria transmission. This makes identifying new insecticide targets or …
Computational Identification of Metabolic Pathways of Plasmodium falciparum using the k‐Shortest Path Algorithm
Plasmodium falciparum, a malaria pathogen, has shown substantial resistance to treatment
coupled with poor response to some vaccines thereby requiring urgent, holistic, and broad …
coupled with poor response to some vaccines thereby requiring urgent, holistic, and broad …
The Central Metabolism Model of Anopheles gambiae: A Tool for Understanding Malaria Vector Biology
Climate change has a profound effect on malaria transmission by influencing malaria
parasites development in mosquitoes, mosquito population dynamics, and longevity. With …
parasites development in mosquitoes, mosquito population dynamics, and longevity. With …
CONTRABASS: exploiting flux constraints in genome-scale models for the detection of vulnerabilities
Motivation Despite the fact that antimicrobial resistance is an increasing health concern, the
pace of production of new drugs is slow due to the high cost and uncertain success of the …
pace of production of new drugs is slow due to the high cost and uncertain success of the …
The Metabolomic Profiles of Sera of Mice Infected with Plasmodiumberghei and Treated by Effective Fraction of Najanajaoxiana Using 1H Nuclear Magnetic …
Background The use of venom fractions from the Iranian cobra could be useful adjunct
treatments of malaria with chloroquine. A metabolomic investigation with 1HNMR …
treatments of malaria with chloroquine. A metabolomic investigation with 1HNMR …
A Systematic Review on Curcumin and Anti-Plasmodium berghei Effects
Background: Turmeric (Curcuma longa L.) is a popular spice containing curcumin that is
responsible for its therapeutic effects. Curcumin with anti-inflammatory, antioxidant, anti …
responsible for its therapeutic effects. Curcumin with anti-inflammatory, antioxidant, anti …