Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China

L Yang, Z Wang - European journal of medicinal chemistry, 2023 - Elsevier
The ongoing COVID-19 pandemic has resulted in millions of deaths globally, highlighting
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …

Molnupiravir and its antiviral activity against COVID-19

L Tian, Z Pang, M Li, F Lou, X An, S Zhu… - Frontiers in …, 2022 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) constitutes a major worldwide public health threat …

Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery

L Leng, Z Xu, B Hong, B Zhao, Y Tian, C Wang… - Nature …, 2024 - nature.com
Cepharanthine is a secondary metabolite isolated from Stephania. It has been reported that
it has anti-conronaviruses activities including severe acute respiratory syndrome …

[HTML][HTML] Natural products, alone or in combination with FDA-approved drugs, to treat COVID-19 and lung cancer

L Yang, Z Wang - Biomedicines, 2021 - mdpi.com
As a public health emergency of international concern, the highly contagious coronavirus
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …

Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage

H Qin, H Qiu, ST He, B Hong, K Liu, F Lou, M Li… - Journal of hazardous …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has become a worldwide public health
emergency, and the high transmission of SARS-CoV-2 variants has raised serious concerns …

Pharmacological activity of cepharanthine

K Liu, B Hong, S Wang, F Lou, Y You, R Hu, A Shafqat… - Molecules, 2023 - mdpi.com
Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant
Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for …

Neutrophil autophagy and NETosis in COVID-19: perspectives

R Zhang, C Sun, Y Han, L Huang, H Sheng, J Wang… - Autophagy, 2023 - Taylor & Francis
The COVID-19 pandemic has caused substantial losses worldwide in people's lives, health,
and property. Currently, COVID-19 is still prominent worldwide without any specific drug …

Dissecting the molecular mechanism of cepharanthine against COVID-19, based on a network pharmacology strategy combined with RNA-sequencing analysis …

J Liu, T Sun, S Liu, J Liu, S Fang, S Tan, Y Zeng… - Computers in Biology …, 2022 - Elsevier
Objectives Recently, it has been reported that cepharanthine (CEP) is highly likely to be an
agent against Coronavirus disease 2019 (COVID-19). In the present study, a network …

Pharmacological effects and clinical prospects of cepharanthine

D Liang, Q Li, L Du, G Dou - Molecules, 2022 - mdpi.com
Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha
Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has …

Cepharanthine: A Promising Old Drug against SARS‐CoV‐2

H Fan, S He, P Han, B Hong, K Liu, M Li… - Advanced …, 2022 - Wiley Online Library
Recently, the inhibiting effects of a clinically approved drug Cepharanthine on severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) have attracted widespread attention and …