Structural biology aims at characterizing the structural and dynamic properties of biological
macromolecules at atomic details. Gaining insight into three dimensional structures of …

Abstract Three-dimensional (3D) structures of protein complexes provide fundamental
information to decipher biological processes at the molecular scale. The vast amount of …

Protein homo-oligomerization is a very common phenomenon, and approximately half of
proteins form homo-oligomeric assemblies composed of identical subunits. The vast majority …

Complexes between proteins are at the basis of almost every process in cells. Their study,
from a structural perspective, has a pivotal role in understanding biological functions and …

A major drawback for practical application of halohydrin dehalogenase HheG in biocatalysis
is its rather low thermal stability and low organic solvent tolerance. We therefore pursued a …

Protein C (PC) is a vitamin K-dependent factor that plays a crucial role in controlling
anticoagulant processes and acts as a cytoprotective agent to promote cell survival. Several …

Type II secretion systems (T2SSs) allow diderm bacteria to secrete hydrolytic enzymes,
adhesins, or toxins important for growth and virulence. To promote secretion of folded …

Protein-protein interactions (PPIs) are fundamental to understanding biological processes
and play a key role in therapeutic advancements. As deep-learning docking methods for …

Staphylococcal exfoliative toxins (ETs) are glutamyl endopeptidases that specifically cleave
the Glu381-Gly382 bond in the ectodomains of desmoglein 1 (Dsg1) via complex action …

The identification of physiologically relevant quaternary structures (QSs) in crystal lattices is
challenging. To predict the physiological relevance of a particular QS, QSalign searches for …