Factors affecting HLA expression: A review

BS Carey, KV Poulton, A Poles - International journal of …, 2019 - Wiley Online Library
The detection and semiquantitative measurement of circulating human leucocyte antigen
(HLA)‐specific antibodies is essential for the management of patients before and after …

Tumor-induced escape mechanisms and their association with resistance to checkpoint inhibitor therapy

M Friedrich, S Jasinski-Bergner, MF Lazaridou… - Cancer Immunology …, 2019 - Springer
Immunotherapy aims to activate the immune system to fight cancer in a very specific and
targeted manner. Despite the success of different immunotherapeutic strategies, in particular …

Comparison between qPCR and RNA-seq reveals challenges of quantifying HLA expression

VRC Aguiar, EC Castelli, RM Single, A Bashirova… - Immunogenetics, 2023 - Springer
Human leukocyte antigen (HLA) class I and II loci are essential elements of innate and
acquired immunity. Their functions include antigen presentation to T cells leading to cellular …

Next-generation sequencing based HLA ty**: deciphering immunogenetic aspects of sarcoidosis

A Kishore, M Petrek - Frontiers in genetics, 2018 - frontiersin.org
Unraveling of the HLA-related immunogenetic basis of several immune disorders is complex
due to the extensive HLA polymorphism and strong linkage-disequilibrium between HLA …

Complete characterization of the human immune cell transcriptome using accurate full-length cDNA sequencing

C Cole, A Byrne, M Adams, R Volden… - Genome …, 2020 - genome.cshlp.org
The human immune system relies on highly complex and diverse transcripts and the
proteins they encode. These include transcripts encoding human leukocyte antigen (HLA) …

The MHC in the era of next-generation sequencing: Implications for bridging structure with function

EW Petersdorf, C O'hUigin - Human immunology, 2019 - Elsevier
The MHC continues to have the most disease-associations compared to other regions of the
human genome, even in the genome-wide association study (GWAS) and single nucleotide …

Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients

MF Lazaridou, E Gonschorek, C Massa… - …, 2020 - Taylor & Francis
Tumor escape is often associated with abnormalities in the surface expression of the human
leukocyte antigen class I (HLA-I) antigens thereby limiting CD8+ cytotoxic T cell responses …

[HTML][HTML] Targeting the coding sequence: opposing roles in regulating classical and non-classical MHC class I molecules by miR-16 and miR-744

M Friedrich, CK Vaxevanis, K Biehl… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background To control gene expression, microRNAs (miRNAs) are of key importance and
their deregulation is associated with the development and progression of various cancer …

ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion

T Kadomatsu, C Hara, R Kurahashi… - Molecular …, 2023 - Wiley Online Library
Loss or downregulation of major histocompatibility complex class I (MHC‐I) contributes to
tumor immune evasion. We previously demonstrated that angiopoietin‐like protein 2 …

Staufen1 interacts with multiple components of the Ebola virus ribonucleoprotein and enhances viral RNA synthesis

J Fang, C Pietzsch, P Ramanathan, RI Santos… - MBio, 2018 - Am Soc Microbiol
Ebola virus (EBOV) genome and mRNAs contain long, structured regions that could hijack
host RNA-binding proteins to facilitate infection. We performed RNA affinity chromatography …