The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

The accurate segregation of chromosomes is essential for the survival of organisms and
cells. Mistakes can lead to aneuploidy, tumorigenesis and congenital birth defects. The …

The interfacing of measurement instrumentation to small computers for the purpose of online
data acquisition has now become standard practice in the modern laboratory. Computerized …

During mitotic entry of vertebrate cells, nuclear pore complexes (NPCs) are rapidly
disintegrated. NPC disassembly is initiated by hyperphosphorylation of linker nucleoporins …

Mitotic spindle is a self-assembling macromolecular machine responsible for the faithful
segregation of chromosomes during cell division. Assembly of the spindle is believed to be …

During mitosis, kinetochore-attached microtubules form bundles (k-fibers) in which many
filaments grow and shorten in near-perfect unison to align and segregate each …

Variation in the chromosome numbers can arise from the erroneous mitosis or fusion and
fission of chromosomes. While the mitotic errors lead to an increase or decrease in the …

Faithful segregation of chromosomes during mitosis relies on a carefully coordinated and
intricate interplay between the centromere, kinetochore, and spindle microtubules. Despite …

Gaussian spot fitting methods have significantly extended the spatial range where
fluorescent microscopy can be used, with recent techniques approaching nanometre (nm) …