Sex differences in type 2 diabetes

A Kautzky-Willer, M Leutner, J Harreiter - Diabetologia, 2023 - Springer
The prevalence of type 2 diabetes mellitus is increasing in both sexes, but men are usually
diagnosed at a younger age and lower body fat mass than women. Worldwide, an estimated …

The expanding incretin universe: from basic biology to clinical translation

DJ Drucker, JJ Holst - Diabetologia, 2023 - Springer
Incretin hormones, principally glucose-dependent insulinotropic polypeptide (GIP) and
glucagon-like peptide-1 (GLP-1), potentiate meal-stimulated insulin secretion through direct …

Incretin hormones and type 2 diabetes

MA Nauck, TD Müller - Diabetologia, 2023 - Springer
abstract Incretin hormones (glucose-dependent insulinotropic polypeptide [GIP] and
glucagon-like peptide-1 [GLP-1]) play a role in the pathophysiology of type 2 diabetes. Along …

The evolving story of incretins (GIP and GLP‐1) in metabolic and cardiovascular disease: a pathophysiological update

MA Nauck, DR Quast, J Wefers… - Diabetes, Obesity and …, 2021 - Wiley Online Library
The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …

[HTML][HTML] Glucagon-like peptide 1 (GLP-1)

TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Sex differences in metabolic regulation and diabetes susceptibility

B Tramunt, S Smati, N Grandgeorge, F Lenfant… - Diabetologia, 2020 - Springer
Gender and biological sex impact the pathogenesis of numerous diseases, including
metabolic disorders such as diabetes. In most parts of the world, diabetes is more prevalent …

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

FM Gribble, F Reimann - Nature Reviews Endocrinology, 2019 - nature.com
Gut hormones have many key roles in the control of metabolism, as they target diverse
tissues involved in the control of intestinal function, insulin secretion, nutrient assimilation …

Incretin hormones: Their role in health and disease

MA Nauck, JJ Meier - Diabetes, Obesity and Metabolism, 2018 - Wiley Online Library
Incretin hormones are gut peptides that are secreted after nutrient intake and stimulate
insulin secretion together with hyperglycaemia. GIP (glucose‐dependent insulinotropic …

Glucagon-like peptide 1 in health and disease

A Andersen, A Lund, FK Knop, T Vilsbøll - Nature Reviews …, 2018 - nature.com
In healthy individuals, the incretin hormone glucagon-like peptide 1 (GLP1) potentiates
insulin release and suppresses glucagon secretion in response to the ingestion of nutrients …

Causes, characteristics, and consequences of metabolically unhealthy normal weight in humans

N Stefan, F Schick, HU Häring - Cell metabolism, 2017 - cell.com
A BMI in the normal range associates with a decreased risk of cardiometabolic disease and
all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared …