Over the last 50 years, the reeler mutant mouse has become an important model for studying
normal and abnormal development in the cerebral cortex and other regions of the brain …

▪ Abstract The neurological mutant mouse reeler has played a critical role in the evolution of
our understanding of normal brain development. From the earliest neuroanatomic studies of …

We characterized the world's second case with ascertained extreme resilience to autosomal
dominant Alzheimer's disease (ADAD). Side-by-side comparisons of this male case and the …

Apolipoprotein E (APOE) is a cholesterol transport protein and an isoform-specific major risk
factor for neurodegenerative diseases. The lipoprotein receptors that bind APOE have …

Reelin, a multifunctional extracellular protein that is important for mammalian brain
development and function, is secreted by different cell types in the prenatal or postnatal …

Background: Reelin is a large signaling molecule that regulates the positioning of neurons
in the mammalian brain. Transmission of the Reelin signal to migrating embryonic neurons …

Reelin was originally identified as a regulator of neuronal migration and synaptic function,
but its non-neuronal functions have received far less attention. Reelin participates in organ …

BACKGROUND: Autism is a severe neurodevelopmental disorder with genetic and
environmental etiologies. Recent genetic linkage studies implicate Reelin glycoprotein in …

Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain:
embryologically, it guides neurons and radial glial cells to their corrected positions in the …

Heterozygous reeler mice (HRM) haploinsufficient for reelin express≈ 50% of the brain
reelin content of wild-type mice, but are phenotypically different from both wild-type mice and …