An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies
Red blood cell (RBC) aging in the blood bank is characterized by the accumulation of a
significant number of biochemical and morphologic alterations. Recent mass spectrometry …
significant number of biochemical and morphologic alterations. Recent mass spectrometry …
Hemolysis derived products toxicity and endothelium: model of the second hit
Vascular diseases are multifactorial, often requiring multiple challenges, or 'hits', for their
initiation. Intra-vascular hemolysis illustrates well the multiple-hit theory where a first event …
initiation. Intra-vascular hemolysis illustrates well the multiple-hit theory where a first event …
Red blood cell and endothelial eNOS independently regulate circulating nitric oxide metabolites and blood pressure
F Leo, T Suvorava, SK Heuser, J Li, A LoBue… - Circulation, 2021 - Am Heart Assoc
Background: Current paradigms suggest that nitric oxide (NO) produced by endothelial cells
(ECs) through endothelial nitric oxide synthase (eNOS) in the vessel wall is the primary …
(ECs) through endothelial nitric oxide synthase (eNOS) in the vessel wall is the primary …
Acute respiratory distress syndrome
ADT Force, VM Ranieri, GD Rubenfeld, B Thompson… - Jama, 2012 - jamanetwork.com
The acute respiratory distress syndrome (ARDS) was defined in 1994 by the American-
European Consensus Conference (AECC); since then, issues regarding the reliability and …
European Consensus Conference (AECC); since then, issues regarding the reliability and …
Transfusion strategies for acute upper gastrointestinal bleeding
C Villanueva, A Colomo, A Bosch… - … England Journal of …, 2013 - Mass Medical Soc
Background The hemoglobin threshold for transfusion of red cells in patients with acute
gastrointestinal bleeding is controversial. We compared the efficacy and safety of a …
gastrointestinal bleeding is controversial. We compared the efficacy and safety of a …
Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study
Genetic polymorphisms in blood donors may contribute to donor-specific differences in the
survival of red blood cells (RBCs) during cold storage and after transfusion. Genetic …
survival of red blood cells (RBCs) during cold storage and after transfusion. Genetic …
Effect of donor, component, and recipient characteristics on hemoglobin increments following red blood cell transfusion
Significant research has focused individually on blood donors, product preparation and
storage, and optimal transfusion practice. To better understand the interplay between these …
storage, and optimal transfusion practice. To better understand the interplay between these …
Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage
Background The evolutionary pressure of endemic malaria and other erythrocytic pathogens
has shaped variation in genes encoding erythrocyte structural and functional proteins …
has shaped variation in genes encoding erythrocyte structural and functional proteins …
Testosterone‐dependent sex differences in red blood cell hemolysis in storage, stress, and disease
T Kanias, D Sinchar, D Osei‐Hwedieh, JJ Baust… - …, 2016 - Wiley Online Library
BACKGROUND Red blood cell (RBC) hemolysis represents an intrinsic mechanism for
human vascular disease. Intravascular hemolysis releases hemoglobin and other …
human vascular disease. Intravascular hemolysis releases hemoglobin and other …
Assessing the influence of component processing and donor characteristics on quality of red cell concentrates using quality control data
Background and Objectives Quality control (QC) data collected by blood services are used
to monitor production and to ensure compliance with regulatory standards. We demonstrate …
to monitor production and to ensure compliance with regulatory standards. We demonstrate …