Sarcomatoid dedifferentiation is an uncommon feature that can occur in most histological
subtypes of renal cell carcinomas (RCCs) and carries a decidedly poor prognosis …

Context Once believed to represent a uniform malignant phenotype, renal cell carcinoma
(RCC) is now viewed as a diverse group of cancers that arise from the nephron. Objective …

Sarcomatoid and rhabdoid (S/R) renal cell carcinoma (RCC) are highly aggressive tumors
with limited molecular and clinical characterization. Emerging evidence suggests immune …

Purpose: Vascular endothelial growth factor targeted therapy is a standard of care in
patients with metastatic renal cell carcinoma. The role of cytoreductive nephrectomy in the …

Patients with metastatic renal cell carcinoma with sarcomatoid features (sRCC) have a poor
prognosis and have shown limited responsiveness to inhibition of the VEGF pathway. We …

Abstract Learning Objectives After completing this course, the reader will be able to:
Describe histologic features associated with sarcomatoid renal cell carcinoma. Outline …

Monoclonal antibodies that target the programmed death-1 (PD-1)–programmed death
ligand-1 (PD-L1) axis have antitumor activity against multiple cancers. The presence of …

OBJECTIVE. The objective of our study was to determine whether CT findings, including
texture analysis, can differentiate sarcomatoid renal cell carcinoma (RCC) from clear cell …

The presence of sarcomatoid features in clear cell renal cell carcinoma (ccRCC) confers a
poor prognosis and is of unknown pathogenesis. We performed exome sequencing of …

Purpose: Sarcomatoid renal cell carcinoma (SRCC) ranks among the most aggressive
clinicopathologic phenotypes of RCC. However, the paucity of high-quality, genome-wide …