Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Radiotherapy is a cornerstone of both curative and palliative cancer care. However,
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …

BACKGROUND An imbalance in the colonic microbiota might underlie many human
diseases, but the mechanisms that balance our microbial self during homeostasis have long …

The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

Bacillus cereus is one of the leading etiological agents of toxin‐induced foodborne
diseases. Its omnipresence in different environments, spore formation, and its ability to adapt …

Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a
majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional …

Highlights•Epithelial hypoxia drives anaerobiosis to maintain dominance of obligate
anaerobes.•Increased epithelial oxygenation disrupts anaerobiosis in the large …

The mammalian intestine is host to a microbial community that prevents pathogen
expansion through unknown mechanisms, while antibiotic treatment can increase …

Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …

The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …