Facile one-pot multicomponent synthesis of peptoid based gelators as novel scaffolds for drug incorporation and pH-sensitive release

S Sebastian, E Yadav, P Bhardwaj, M Maruthi… - Journal of Materials …, 2023 - pubs.rsc.org
Infections caused by bacteria are the primary cause of illness and death globally, and
antibiotics are the most commonly used medications to treat them. However, there are …

Supramolecular organo/hydrogel-fabricated long alkyl chain α-amidoamides as a smart soft material for pH-responsive curcumin release

S Sebastian, Y Rohila, E Yadav, P Bhardwaj… - …, 2024 - ACS Publications
Low-molecular-mass gelators, due to their excellent biocompatibility, low toxicological
profile, innate biodegradability and ease of fabrication have garnered significant interest as …

Application of inorganic nanomaterials in transdermal and topical medications: influential parameters, opportunities and challenges

M Servatan, P Mutlu, S Ertunç… - Comments on …, 2024 - Taylor & Francis
Recent advances in nanotechnology are expected to assist scientists in solving many key
obstacles in biological complications. During the last decade, a great deal of research …

Atom-economical synthesis, antimicrobial assessment, and molecular dynamics of indole-derived peptidomimetics for improved therapeutic insights

S Sebastian, Y Rohila, S Prakash, A Kumar… - Journal of Molecular …, 2024 - Elsevier
The emergence of multi-drug resistant strains spanning bacteria, fungi, viruses, and
parasites poses a severe threat to public health and the economy. Tackling antimicrobial …

Anti-quorum sensing activity of α-amidoamides against Agrobacterium tumefaciensNT1: Insights from molecular docking and dynamic investigations to synergistic …

S Sebastian, Y Rohila, A Ansari, S Sengupta… - Microbial …, 2024 - Elsevier
A unique approach is imperative for the development of drugs aimed at inhibiting various
stages of infection, rather than solely focusing on bacterial viability. Among the array of …

N‐Hydroxyalkanamide Based Organo/hydrogels as Novel Scaffolds for pH‐Dependent Metronidazole and Theophylline Release

Monika, Meenakshi, M Brahma, M Maruthi… - Chemistry & …, 2024 - Wiley Online Library
The traditional delivery of metronidazole and theophylline presents challenges like bitter
taste, variable absorption, and side effects. However, gel‐based systems offer advantages …

Photopatterned Hybrid Supramolecular/Polymer Hydrogels for Controlled Heparin Release and Stem Cell Growth

Á López‐Acosta, PRA Chivers, CC Piras… - …, 2024 - Wiley Online Library
This paper reports hybrid gels combining a low‐molecular‐weight gelator (LMWG) and a
photoinitiated crosslinked polymer gel (PG). The presence of the PG enhanced the stiffness …

Fabrication of targeted PDA-Hemin-Dox-FA nanoplatform for enhanced chemodynamic therapy synergized with chemo/photothermal therapy

Y Wang, N Zheng, Z Zhang, H Ma, Y Wei - Colloids and Surfaces A …, 2023 - Elsevier
Chemotherapy (CT) is widely used in clinical practice due to its simple and convenient
steps, but its characteristics of systemic administration also results in a lack of targeting and …

Environmentally benign self-assembled biopolymer-peptoid nanosilver composite hybrid gel beads via ion-crosslinking for antimicrobial and catalytic applications

S Sebastian, Y Rohila, A Ansari, S Prakash… - Applied Materials …, 2024 - Elsevier
Silver nanoparticles are gaining significant attention due to their exceptional versatility
arising from their unique combination of size, surface properties, and inherent reactivity. This …

Unveiling Gelation and Antimicrobial Potentials of α‐Acyloxy Carboxamides: Findings from Experimental and Theoretical Approach

S Sebastian, M Kumar, F Hussain, S Rathore… - ChemMedChem - Wiley Online Library
Multicomponent reactions have long been recognized as some of the most versatile tools in
organic chemistry, with extensive applications in biomedical science and the pharmaceutical …