Retrovirus packaging cells
AD Miller - Human gene therapy, 1990 - liebertpub.com
Retroviral vectors promote the efficient transfer of genes into a variety of cell types from
many animal species. An important contribution to their utility was the development of …
many animal species. An important contribution to their utility was the development of …
Gene therapy for cancer: what have we done and where are we going?
JA Roth, RJ Cristiano - Journal of the National Cancer Institute, 1997 - academic.oup.com
Gene-based therapies for cancer in clinical trials include strategies that involve
augmentation of immunotherapeutic and chemotherapeutic approaches. These strategies …
augmentation of immunotherapeutic and chemotherapeutic approaches. These strategies …
Regeneration of the entire human epidermis using transgenic stem cells
Junctional epidermolysis bullosa (JEB) is a severe and often lethal genetic disease caused
by mutations in genes encoding the basement membrane component laminin-332 …
by mutations in genes encoding the basement membrane component laminin-332 …
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
JP Morgenstern, H Land - Nucleic acids research, 1990 - academic.oup.com
We report the development of an advanced system for transfer and expression of exogenous
genes in mammalian cells based on Moloney murine leukemia virus (Mo MuLV). Extensive …
genes in mammalian cells based on Moloney murine leukemia virus (Mo MuLV). Extensive …
[HTML][HTML] A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
JR Bischoff, L Anderson, Y Zhu, K Mossie, L Ng… - The EMBO …, 1998 - embopress.org
Genetic and biochemical studies in lower eukaryotes have identified several proteins that
ensure accurate segregation of chromosomes. These include the Drosophila aurora and …
ensure accurate segregation of chromosomes. These include the Drosophila aurora and …
[HTML][HTML] Improved retroviral vectors for gene transfer and expression
AD Miller, GJ Rosman - Biotechniques, 1989 - ncbi.nlm.nih.gov
We describe a set of murine retrovirus-based vectors that include unique cloning sites for
insertion of cDNAs such that the cDNA can be driven by either the retroviral long terminal …
insertion of cDNAs such that the cDNA can be driven by either the retroviral long terminal …
The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses
We describe the construction and characterization of retroviral vectors and packaging
plasmids that produce helper-free retrovirus with titers of 1 X 10 (6) to 5 X 10 (6) within 48 h …
plasmids that produce helper-free retrovirus with titers of 1 X 10 (6) to 5 X 10 (6) within 48 h …
Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes
JD Flax, S Aurora, C Yang, C Simonin, AM Wills… - Nature …, 1998 - nature.com
Stable clones of neural stem cells (NSCs) have been isolated from the human fetal
telencephalon. These self-renewing clones give rise to all fundamental neural lineages in …
telencephalon. These self-renewing clones give rise to all fundamental neural lineages in …
[HTML][HTML] Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
E Kroon, J Krosl, U Thorsteinsdottir, S Baban… - The EMBO …, 1998 - embopress.org
Abstract Hoxa9, Meis1 and Pbx1 encode homeodomaincontaining proteins implicated in
leukemic transformation in both mice and humans. Hoxa9, Meis1 and Pbx1 proteins have …
leukemic transformation in both mice and humans. Hoxa9, Meis1 and Pbx1 proteins have …
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.
Hox genes were first recognized for their role in embryonic development and may also play
important lineage-specific functions in a variety of somatic tissues including the …
important lineage-specific functions in a variety of somatic tissues including the …