Cardiovascular diseases (CVDs) continue to be a major global health concern, representing
a leading cause of morbidity and mortality. This review provides a comprehensive …

Heart failure (HF) is a complex disease in which cardiomyocyte injury leads to a cascade of
inflammatory and fibrosis pathway activation, thereby causing decrease in cardiac function …

The heart's pum** capacity results from highly regulated interactions of actomyosin
molecular motors. Mutations in the gene for a potential regulator of these motors, cardiac …

The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and
regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point …

BACKGROUND Myocardial infarction is diagnosed when biomarkers of cardiac necrosis
exceed the 99th centile, although guidelines advocate even lower concentrations for early …

Despite the growing number of patients affected, the understanding of diastolic dysfunction
and heart failure with preserved ejection fraction (HFpEF) is still poor. Clinical trials, largely …

Skeletal muscle, a highly complex muscle type in the eukaryotic system, is characterized by
different muscle subtypes and functions associated with specific myosin isoforms. As a …

Sarcomeres consist of highly ordered arrays of thick myosin and thin actin filaments along
with accessory proteins. Thick filaments occupy the center of sarcomeres where they …

Myosin-binding protein C (MyBP-C) is a critical regulator of muscle performance that was
first identified through its strong binding interactions with myosin, the force-generating …

Mutations of cardiac myosin binding protein-C (cMyBP-C) are inherited by an estimated 60
million people worldwide, and the protein is the target of several kinases. Recent evidence …