Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …

Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …

The function of interleukin-22 (IL-22) in intestinal barrier homeostasis remains controversial.
Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial …

Psoriasis is a frequent inflammatory skin disease. Fundamental research on the
pathogenesis of psoriasis has substantially increased our understanding of skin …

Upon antigenic stimulation, naïve CD4+ T cells differentiate into different subsets and
secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+ T …

Bone is a common site of metastasis in lung cancer, but the regulatory mechanism remains
incompletely understood. Osteoclasts are known to play crucial roles in osteolytic bone …

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …

The barrier surfaces of the gastrointestinal tract are in constant contact with various
microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the …

Autoimmune skin diseases are characterized by significant local and systemic inflammation
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …

Abstract Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells,
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …