Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery
G protein-coupled receptors (GPCRs) are the largest human membrane protein family that
transduce extracellular signals into cellular responses. They are major pharmacological …
transduce extracellular signals into cellular responses. They are major pharmacological …
Nanodiscs for the study of membrane proteins
Nanodiscs represent a versatile tool for studies of membrane proteins and protein-
membrane interactions under native-like conditions. Multiple variations of the Nanodisc …
membrane interactions under native-like conditions. Multiple variations of the Nanodisc …
[HTML][HTML] Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies
A Fouillen, P Couvineau, G Gaibelet, S Riché… - Computational and …, 2024 - Elsevier
G protein-coupled receptors (GPCRs) control critical cell signaling. Their response to
extracellular stimuli involves conformational changes to convey signals to intracellular …
extracellular stimuli involves conformational changes to convey signals to intracellular …
The critical importance of conditions: Reconciling GPCR functionality and biophysical findings
G-protein-coupled receptor (GPCR) activation relies on conformational sampling, a nuanced
but functionally key behavior well suited to elucidation by nuclear magnetic resonance …
but functionally key behavior well suited to elucidation by nuclear magnetic resonance …
[HTML][HTML] The conformational equilibria of a human GPCR compared between lipid vesicles and aqueous solutions by integrative 19F-NMR
Endogenous phospholipids influence the conformational equilibria of G protein-coupled
receptors, regulating their ability to bind drugs and form signaling complexes. However …
receptors, regulating their ability to bind drugs and form signaling complexes. However …