Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Lysosomes are the primary degradative compartment within cells and there have been
significant advances over the past decade toward understanding how lysosome …

Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative
phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade …

Mutations in the E3 ubiquitin ligase parkin are the most common cause of early-onset
Parkinson's disease (PD). Although parkin modulates mitochondrial and endolysosomal …

Understanding the mechanisms governing selective turnover of mutation-bearing mtDNA is
fundamental to design therapeutic strategies against mtDNA diseases. Here, we show that …

Abstract Introduction Mutations in GDAP1 (Ganglioside-induced differentiation-associated
protein 1) gene are linked to Charcot-Marie-Tooth disease (CMT), a Heterogenous group of …

Neurodegenerative diseases (NDs) are generally considered proteinopathies but whereas
this may initiate disease in familial cases, onset in sporadic diseases may originate from a …

Charcot-Marie-Tooth (CMT) disease is a progressive, peripheral neuropathy and the most
commonly inherited neurological disorder. Clinical manifestations of CMT mutations are …

Parkinson's disease (PD) is a neurodegenerative disease caused by multifactorial
pathogenic mechanisms. Familial PD is linked with genetic mutations in genes whose …

Mitochondrial dysfunction is a central feature of neurodegeneration within the central and
peripheral nervous system, highlighting a strong dependence on proper mitochondrial …