An insight on functioning pancreatic neuroendocrine neoplasms

M Bevere, A Gkountakos, FM Martelli, A Scarpa… - Biomedicines, 2023 - mdpi.com
Pancreatic neuroendocrine neoplasms (PanNENs) are rare neoplasms arising from islets of
the Langerhans in the pancreas. They can be divided into two groups, based on peptide …

The uprise of RNA biology in neuroendocrine neoplasms: altered splicing and RNA species unveil translational opportunities

R Blázquez-Encinas, MT Moreno-Montilla… - Reviews in Endocrine …, 2023 - Springer
Neuroendocrine neoplasms (NENs) comprise a highly heterogeneous group of tumors
arising from the diffuse neuroendocrine system. NENs mainly originate in gastrointestinal …

Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors PRPF8 and RBMX as novel candidate actionable targets

E Alors‐Pérez, R Blázquez‐Encinas… - Molecular …, 2024 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, characterized by late
diagnosis and poor treatment response. Surgery is the only curative approach, only …

Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing

JL López‐Cánovas, N Hermán‐Sánchez… - Clinical and …, 2022 - Wiley Online Library
Introduction Altered splicing landscape is an emerging cancer hallmark; however, the
dysregulation and implication of the cellular machinery controlling this process (spliceosome …

Comprehensive analysis of alternative splicing across multiple transcriptomic cohorts reveals prognostic signatures in prostate cancer

Z Mou, J Spencer, JS McGrath, LW Harries - Human Genomics, 2023 - Springer
Background Alternative splicing (AS) plays a crucial role in transcriptomic diversity and is a
hallmark of cancer that profoundly influences the development and progression of prostate …

[HTML][HTML] Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus response

E Alors-Pérez, S Pedraza-Arevalo… - … Therapy-Nucleic Acids, 2024 - cell.com
Pancreatic neuroendocrine tumors (PanNETs) comprise a heterogeneous group of tumors
with growing incidence. Recent molecular analyses provided a precise picture of their …

[HTML][HTML] Methylation-related differentially expressed genes as potential prognostic biomarkers for cervical cancer

Y Chen, Q Zou, Q Chen, S Wang, Q Du, Q Mai, X Wang… - Heliyon, 2024 - cell.com
Aim To discover novel methylation-related differentially expressed genes (MRDEGs) for
cervical cancer, with a focus on their potential for early diagnosis and prognostic …

Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery

R Blázquez-Encinas, V García-Vioque… - Journal of translational …, 2023 - Springer
Abstract Background Lung neuroendocrine neoplasms (LungNENs) comprise a
heterogeneous group of tumors ranging from indolent lesions with good prognosis to highly …

The splicing machinery is dysregulated and represents a therapeutic vulnerability in breast cancer

N Hermán-Sánchez, ME G-García… - Cellular and Molecular …, 2024 - Springer
Breast cancer (BCa) is a highly prevalent pathological condition (̴30% in women) with
limited and subtype-dependent prognosis and therapeutic options. Therefore, BCa …

Administration of A. muciniphila ameliorates pulmonary arterial hypertension by targeting miR-208a-3p/NOVA1 axis

Z Bao, H Li, S Zhang, Y Fei, M Yao, L Li - Acta Pharmacologica Sinica, 2023 - nature.com
Pulmonary arterial hypertension (PH) is a chronic disease induced by a progressive
increase in pulmonary vascular resistance and failure of the right heart function. A number of …