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An insight on functioning pancreatic neuroendocrine neoplasms
Pancreatic neuroendocrine neoplasms (PanNENs) are rare neoplasms arising from islets of
the Langerhans in the pancreas. They can be divided into two groups, based on peptide …
the Langerhans in the pancreas. They can be divided into two groups, based on peptide …
The uprise of RNA biology in neuroendocrine neoplasms: altered splicing and RNA species unveil translational opportunities
R Blázquez-Encinas, MT Moreno-Montilla… - Reviews in Endocrine …, 2023 - Springer
Neuroendocrine neoplasms (NENs) comprise a highly heterogeneous group of tumors
arising from the diffuse neuroendocrine system. NENs mainly originate in gastrointestinal …
arising from the diffuse neuroendocrine system. NENs mainly originate in gastrointestinal …
Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors PRPF8 and RBMX as novel candidate actionable targets
E Alors‐Pérez, R Blázquez‐Encinas… - Molecular …, 2024 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, characterized by late
diagnosis and poor treatment response. Surgery is the only curative approach, only …
diagnosis and poor treatment response. Surgery is the only curative approach, only …
Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing
JL López‐Cánovas, N Hermán‐Sánchez… - Clinical and …, 2022 - Wiley Online Library
Introduction Altered splicing landscape is an emerging cancer hallmark; however, the
dysregulation and implication of the cellular machinery controlling this process (spliceosome …
dysregulation and implication of the cellular machinery controlling this process (spliceosome …
Comprehensive analysis of alternative splicing across multiple transcriptomic cohorts reveals prognostic signatures in prostate cancer
Background Alternative splicing (AS) plays a crucial role in transcriptomic diversity and is a
hallmark of cancer that profoundly influences the development and progression of prostate …
hallmark of cancer that profoundly influences the development and progression of prostate …
[HTML][HTML] Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus response
Pancreatic neuroendocrine tumors (PanNETs) comprise a heterogeneous group of tumors
with growing incidence. Recent molecular analyses provided a precise picture of their …
with growing incidence. Recent molecular analyses provided a precise picture of their …
[HTML][HTML] Methylation-related differentially expressed genes as potential prognostic biomarkers for cervical cancer
Y Chen, Q Zou, Q Chen, S Wang, Q Du, Q Mai, X Wang… - Heliyon, 2024 - cell.com
Aim To discover novel methylation-related differentially expressed genes (MRDEGs) for
cervical cancer, with a focus on their potential for early diagnosis and prognostic …
cervical cancer, with a focus on their potential for early diagnosis and prognostic …
Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery
R Blázquez-Encinas, V García-Vioque… - Journal of translational …, 2023 - Springer
Abstract Background Lung neuroendocrine neoplasms (LungNENs) comprise a
heterogeneous group of tumors ranging from indolent lesions with good prognosis to highly …
heterogeneous group of tumors ranging from indolent lesions with good prognosis to highly …
The splicing machinery is dysregulated and represents a therapeutic vulnerability in breast cancer
N Hermán-Sánchez, ME G-García… - Cellular and Molecular …, 2024 - Springer
Breast cancer (BCa) is a highly prevalent pathological condition (̴30% in women) with
limited and subtype-dependent prognosis and therapeutic options. Therefore, BCa …
limited and subtype-dependent prognosis and therapeutic options. Therefore, BCa …
Administration of A. muciniphila ameliorates pulmonary arterial hypertension by targeting miR-208a-3p/NOVA1 axis
Pulmonary arterial hypertension (PH) is a chronic disease induced by a progressive
increase in pulmonary vascular resistance and failure of the right heart function. A number of …
increase in pulmonary vascular resistance and failure of the right heart function. A number of …