The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …

Proteogenomics is an area of research at the interface of proteomics and genomics. In this
approach, customized protein sequence databases generated using genomic and …

Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct
biochemical processes into discrete subcellular locations. Microscopy and biochemical …

We describe pLink 2, a search engine with higher speed and reliability for proteome-scale
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …

Abstract 53BP1 is a chromatin-binding protein that regulates the repair of DNA double-
strand breaks by suppressing the nucleolytic resection of DNA termini,. This function of …

Summary mRNA processing, transport, translation, and ultimately degradation involve a
series of dedicated protein complexes that often assemble into large membraneless …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

Inflammasome is an intracellular signaling complex of the innate immune system. Activation
of inflammasomes promotes the secretion of interleukin 1β (IL-1β) and IL-18 and triggers …

Reproducibility in research can be compromised by both biological and technical variation,
but most of the focus is on removing the latter. Here we investigate the effects of biological …

The proteasome, the primary protease for ubiquitin-dependent proteolysis in eukaryotes, is
usually found as a mixture of 30S, 26S, and 20S complexes. These complexes have …