The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

Senescent cells drive age-related tissue dysfunction partially through the induction of a
chronic senescence-associated secretory phenotype (SASP). Mitochondria are major …

Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell
death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM) …

The BCL-2 family protein BAX is a major regulator of physiological and pathological cell
death. BAX predominantly resides in the cytosol in a quiescent state and upon stress, it …

Mitochondria have emerged as key drivers of mammalian innate immune responses,
functioning as signaling hubs to trigger inflammation and orchestrating metabolic switches …

Apoptotic cell death is implicated in both physiological and pathological processes. Since
many types of cancerous cells intrinsically evade apoptotic elimination, induction of …

Abstract BCL-2-associated X protein (BAX) is a promising therapeutic target for activating or
restraining apoptosis in diseases of pathologic cell survival or cell death, respectively. In …

Solvent paramagnetic relaxation enhancement (sPRE) is a versatile nuclear magnetic
resonance (NMR)-based method that allows characterization of the structure and dynamics …

For over two decades, the development of B-cell lymphoma-2 (Bcl-2) family therapeutics has
primarily focused on anti-apoptotic proteins, resulting in the first-in-class drugs called BH3 …