Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process
found in many malignant tumors, and is different from the traditional angiogenetic process …

Beginning in the first trimester, fetally derived extravillous trophoblasts (EVTs) invade the
uterus and remodel its spiral arteries, transforming them into large, dilated blood vessels …

The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …

Physiological and molecular processes initiated during implantation for pregnancy success
are complex but highly organized. This review primarily highlights adverse ripple effects …

In preeclampsia (PE), cytotrophoblast (CTB) invasion of the uterus and spiral arteries is often
shallow. Thus, the placenta's role has been a focus. In this study, we tested the hypothesis …

The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …

Human trophoblast stem cells (hTSCs) derived from blastocysts and first-trimester
cytotrophoblasts offer an unprecedented opportunity to study the placenta. However, access …

Preeclampsia is a disorder specific of the human being that appears after 20 weeks of
pregnancy, characterized by new onset of hypertension and proteinuria. Abnormal …

Correct development of the human placenta and its differentiated epithelial cells, syncytial
trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful …