Glioblastoma therapy: Past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Glioblastoma: current status, emerging targets, and recent advances

A Thakur, C Faujdar, R Sharma, S Sharma… - Journal of Medicinal …, 2022 - ACS Publications
Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

An overview of EGFR mechanisms and their implications in targeted therapies for glioblastoma

SMB Rodriguez, A Kamel, GV Ciubotaru… - International Journal of …, 2023 - mdpi.com
Despite all of the progress in understanding its molecular biology and pathogenesis,
glioblastoma (GBM) is one of the most aggressive types of cancers, and without an efficient …

Molecular markers in glioma

K Ludwig, HI Kornblum - Journal of neuro-oncology, 2017 - Springer
Gliomas are the most malignant and aggressive form of brain tumors, and account for the
majority of brain cancer related deaths. Malignant gliomas, including glioblastoma are …

The role of hypoxia in glioblastoma invasion

AR Monteiro, R Hill, GJ Pilkington, PA Madureira - Cells, 2017 - mdpi.com
Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly
type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 …

Updated insights on EGFR signaling pathways in glioma

A Oprita, SC Baloi, GA Staicu, O Alexandru… - International journal of …, 2021 - mdpi.com
Nowadays, due to recent advances in molecular biology, the pathogenesis of glioblastoma
is better understood. For the newly diagnosed, the current standard of care is represented by …

Glioma stem cells and their roles within the hypoxic tumor microenvironment

NH Boyd, AN Tran, JD Bernstock, T Etminan… - …, 2021 - pmc.ncbi.nlm.nih.gov
Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …

Delivery of functional anti-miR-9 by mesenchymal stem cell–derived exosomes to glioblastoma multiforme cells conferred chemosensitivity

JL Munoz, SA Bliss, SJ Greco, SH Ramkissoon… - … therapy Nucleic acids, 2013 - cell.com
Glioblastoma multiforme (GBM), the most common and lethal tumor of the adult brain,
generally shows chemo-and radioresistance. MicroRNAs (miRs) regulate physiological …

Challenges in glioblastoma immunotherapy: mechanisms of resistance and therapeutic approaches to overcome them

KJ Habashy, R Mansour, C Moussalem… - British journal of …, 2022 - nature.com
Glioblastoma is the most common and aggressive primary malignant brain tumour. The
prognosis of patients with glioblastoma is poor, and their overall survival averages at 1 year …

Anticancer mechanism of curcumin on human glioblastoma

SC Wong, MNA Kamarudin, R Naidu - Nutrients, 2021 - mdpi.com
Glioblastoma (GBM) is the most malignant brain tumor and accounts for most adult brain
tumors. Current available treatment options for GBM are multimodal, which include surgical …