NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen
species (ROS). Numerous homologue-specific mechanisms control the activity of this …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Phosphatidylserine recognition receptors are a highly diverse set of receptors grouped by
their ability to recognize the 'eat‐me'signal phosphatidylserine on apoptotic cells. Most of the …

RhoA GTPase plays a variety of functions in regulation of cytoskeletal proteins, cellular
morphology, and migration along with various proliferation and transcriptional activity in …

Emerging studies revealed that the Aryl hydrocarbon receptor (AhR), a receptor sensing
environmental contaminants, is executing an immunomodulatory function. However, it is an …

Neutrophils are mobilized and recruited to the injured heart after myocardial infarction, and
neutrophil count has been clinically implicated to be associated with coronary disease …

In the Wnt canonical pathway, Wnt3A has been known to stabilize β-catenin. In the non-
canonical Wnt signaling pathway, Wnt is known to activate Rho GTPases. The correlation …

Integrin-mediated adhesion is a general concept referring to a series of adhesive
phenomena including tethering–rolling, affinity, valency, and binding stabilization altogether …

In canonical pathway, Wnt3A has been known to stabilize β‐catenin through the dissociation
between β‐catenin and glycogen synthase kinase‐3β (GSK‐3β) that suppresses the …

Metastatic melanoma is challenging to clinically address. Although standard-of-care
targeted therapy has high response rates in patients with BRAF-mutant melanoma, therapy …