Therapeutic significance of β-glucuronidase activity and its inhibitors: A review
The emergence of disease and dearth of effective pharmacological agents on most
therapeutic fronts, constitutes a major threat to global public health and man's existence …
therapeutic fronts, constitutes a major threat to global public health and man's existence …
Design and synthesis of 2-amino-4,6-diarylpyrimidine derivatives as potent α-glucosidase and α-amylase inhibitors: structure–activity relationship, in vitro, QSAR …
In the present study, a series of 2-amino-4, 6-diarylpyrimidine derivatives was designed,
synthesized, characterized and evaluated for their in vitro α-glucosidase and α-amylase …
synthesized, characterized and evaluated for their in vitro α-glucosidase and α-amylase …
A novel series of mixed-ligand M (II) complexes containing 2, 2′-bipyridyl as potent α-glucosidase inhibitor: synthesis, crystal structure, DFT calculations, and …
Diabetes mellitus (DM) is a common degenerative disease and characterized by high blood
glucose levels. Since the effective antidiabetic treatments attempt to decrease blood glucose …
glucose levels. Since the effective antidiabetic treatments attempt to decrease blood glucose …
[HTML][HTML] Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review
T Zhang, M Li, J Lu, J Wang, M Zhang… - Molecules, 2025 - mdpi.com
Quinones, one of the oldest organic compounds, are of increasing interest due to their
abundant presence in a wide range of natural sources and their remarkable biological …
abundant presence in a wide range of natural sources and their remarkable biological …
Three novel Cu (II), Cd (II) and Cr (III) complexes of 6− Methylpyridine− 2− carboxylic acid with thiocyanate: Synthesis, crystal structures, DFT calculations, molecular …
Abstract Novel complexes of 6− methylpyridine− 2− carboxylic acid and thiocyanate {[Cu
(NCS)(6-mpa) 2],(1);[Cd (NCS)(6-mpa)] n,(2);[Cr (NCS)(6-mpa) 2· H 2 O],(3)} were …
(NCS)(6-mpa) 2],(1);[Cd (NCS)(6-mpa)] n,(2);[Cr (NCS)(6-mpa) 2· H 2 O],(3)} were …
A new dinuclear copper (II) complex of 2, 5–Furandicarboxyclic acid with 4 (5)‐Methylimidazole as a high potential α‐glucosidase inhibitor: Synthesis, Crystal structure …
A new dinuclear copper (II) complex of 2, 5–furandicarboxyclic acid with 4 (5)‐
methylimidazole,[Cu (FDCA)((4 (5) MeI) 2] 2· 2H2O, was synthesized, and its structure …
methylimidazole,[Cu (FDCA)((4 (5) MeI) 2] 2· 2H2O, was synthesized, and its structure …
α-Glucosidase inhibitory effect of rhinacanthins-rich extract from Rhinacanthus nasutus leaf and synergistic effect in combination with acarbose
Rhinacanthins-rich extract (RRE) from Rhinacanthus nasutus leaf and its marker
compounds namely rhinacanthin-C, rhinacanthin-D and rhinacanthin-N were evaluated for α …
compounds namely rhinacanthin-C, rhinacanthin-D and rhinacanthin-N were evaluated for α …
New 1, 2, 3‐triazole–(thio) barbituric acid hybrids as urease inhibitors: design, synthesis, in vitro urease inhibition, docking study, and molecular dynamic simulation
Abstract A new series of 1, 2, 3‐triazole–(thio) barbituric acid hybrids 8a–n was designed
and synthesized on the basis of potent pharmacophores with urease inhibitory activity …
and synthesized on the basis of potent pharmacophores with urease inhibitory activity …
Design and synthesis of thiobarbituric acid analogues as potent urease inhibitors
A series of thiobarbiturates 4a–4e and bis-thiobarbiturates analogues 5a–5o has been
synthesized by condensing 1, 3-diethylthiobarbituric acid 3 with a variety of aromatic …
synthesized by condensing 1, 3-diethylthiobarbituric acid 3 with a variety of aromatic …
Synthesis and Biological Evaluation of Novel Benzylidene Thiazolo Pyrimidin-3(5H)-One Derivatives
Starting compound 1 was synthesized according to reference. Benzylidene thiazole
pyrimidin-3 (5 H)-ones were synthesized reactions of 1 with bromoacetic acid and various …
pyrimidin-3 (5 H)-ones were synthesized reactions of 1 with bromoacetic acid and various …