The sine oculis homeobox (SIX) protein family is a group of evolutionarily conserved
transcription factors that are found in diverse organisms that range from flatworms to …

Cranial placodes (which include the adenohypophyseal, olfactory, lens, otic, lateral line,
profundal/trigeminal, and epibranchial placodes) give rise to many sense organs and …

In the vertebrate head, crucial parts of the sense organs and sensory ganglia develop from
special regions, the cranial placodes. Despite their cellular and functional diversity, they …

The otic primordium belongs to a group of related structures, the sensory placodes that
contribute to the paired sense organs-ear, eye and olfactory epithelium-and to the distal …

Drosophila eye development has been extensively studied, due to the ease of genetic
screens for mutations disrupting this process. The eye imaginal disc is specified during …

Nephron endowment is determined by the self-renewal and induction of a nephron
progenitor pool established at the onset of kidney development. In the mouse, the related …

The homeobox gene superfamily encodes transcription factors that act as master regulators
of development through their ability to activate or repress a diverse range of downstream …

Background The SIX family homeobox genes have been demonstrated to be involved in the
tumor initiation and progression, but their clinicopathological features and prognostic values …

Among the mechanisms that steer cells to their correct fate during development, master
regulatory networks are unique in their sufficiency to trigger a developmental program …

Abstract Sine Oculis Homeobox 1 (SIX1) is a member of homeobox transcription factor
family having pivotal roles in organismal development and differentiation. This protein …