The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …

X-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription
factor whose dynamic form is controlled by an alternative splicing response upon …

Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …

The protein chaperone GRP78 is a master regulator of endoplasmic reticulum (ER) functions
and is frequently over-expressed at the surface of cancer cells where it contributes to chemo …

Inhibition of p97, a key player in the ubiquitin-proteasome degradation pathway, has been
proposed as a treatment of cancer. This concept was nearly realized recently when a potent …

The unfolded protein response (UPR) is an evolutionarily conserved adaptive signaling
pathway triggered by a stress of the endoplasmic reticulum (ER) lumen compartment, which …

Circular RNAs (circRNAs) are a novel class of powerful regulators in gene expression and
participate in the pathogenesis of many diseases, including cancer. However, little is known …

Background Acute myeloid leukemia (AML) is a common hematopoietic malignancy with
invasive activity. Drug resistance greatly contributes to the poor efficacy of chemotherapy in …

Simple Summary Blood malignancies account for 6.9% of all cancer deaths. Inositol-
requiring enzyme 1 alpha (IRE1α), a part of the unfolded protein response (UPR), has been …

VCP/p97/Cdc48, a member of the ATPases associated with diverse cellular activities (AAA)
family, is necessary for the endoplasmic-reticulum-associated protein degradation (ERAD) …