Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Atherosclerosis, the leading cause of death in the developed world and nearly the leading
cause in the develo** world, is associated with systemic risk factors including …

Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …

On the 400th anniversary of Harvey's Lumleian lectures, this review focuses on
“hemodynamic” forces associated with the movement of blood through arteries in humans …

Cells within tissues are continuously exposed to physical forces including hydrostatic
pressure, shear stress, and compression and tension forces. Cells dynamically adapt to …

Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

The vascular endothelium is an interface between the blood stream and the vessel wall.
Changes in this single cell layer of the artery wall are believed of primary importance in the …

Endothelium lining the cardiovascular system is highly sensitive to hemodynamic shear
stresses that act at the vessel luminal surface in the direction of blood flow. Physiological …

Mechanical forces are important modulators of cellular function in many tissues and are
particularly important in the cardiovascular system. The endothelium, by virtue of its unique …