The 2007 WHO classification of tumours of the central nervous system
The fourth edition of the World Health Organization (WHO) classification of tumours of the
central nervous system, published in 2007, lists several new entities, including angiocentric …
central nervous system, published in 2007, lists several new entities, including angiocentric …
PTEN and the PI3-kinase pathway in cancer
N Chalhoub, SJ Baker - Annual Review of Pathology …, 2009 - annualreviews.org
PI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-
kinase pathway, which regulates growth, survival, and proliferation. These key signaling …
kinase pathway, which regulates growth, survival, and proliferation. These key signaling …
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
F Toledo, GM Wahl - Nature Reviews Cancer, 2006 - nature.com
Mutations in TP53, the gene that encodes the tumour suppressor p53, are found in 50% of
human cancers, and increased levels of its negative regulators MDM2 and MDM4 (also …
human cancers, and increased levels of its negative regulators MDM2 and MDM4 (also …
The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations
PIK3CA, one of the two most frequently mutated oncogenes in human tumors, codes for
p110α, the catalytic subunit of a phosphatidylinositol 3-kinase, isoform α (PI3Kα …
p110α, the catalytic subunit of a phosphatidylinositol 3-kinase, isoform α (PI3Kα …
Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises
TA Yap, MD Garrett, MI Walton, F Raynaud… - Current opinion in …, 2008 - Elsevier
The strategy of 'drugging the cancer kinome'has led to the successful development and
regulatory approval of several novel molecular targeted agents. The spotlight is now shifting …
regulatory approval of several novel molecular targeted agents. The spotlight is now shifting …
Oncogenic mutations of PIK3CA in human cancers
The involvement of the PIK3CA gene product p110α, the catalytic subunit of
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …
Oncogenic PI3K and its role in cancer
Y Samuels, K Ericson - Current opinion in oncology, 2006 - journals.lww.com
The PI3K signaling pathway is dysregulated by a variety of mechanisms in a large fraction of
human tumors. Both mutational and functional analyses have shown that PIK3CA is an …
human tumors. Both mutational and functional analyses have shown that PIK3CA is an …
PI3K/PTEN signaling in tumorigenesis and angiogenesis
BH Jiang, LZ Liu - Biochimica et biophysica acta (bba)-proteins and …, 2008 - Elsevier
The phosphatidyl inositol 3-kinase (PI3K) can be activated by a variety of extracellular
signals and involved in a number of cellular processes including cell proliferation, survival …
signals and involved in a number of cellular processes including cell proliferation, survival …
[LIBRO][B] Principles and practice of pediatric neurosurgery
L Albright, IF Pollack, D Adelson, R Abbott… - 2008 - thieme-connect.com
Thieme E-Books & E-Journals DE EN Home Products Journals Books Book Series Service
Library Service Help Contact Portal Full-text search Full-text search Author Search Title Search …
Library Service Help Contact Portal Full-text search Full-text search Author Search Title Search …
Glioblastoma: morphologic and molecular genetic diversity
Abstract Context.—Glioblastoma (GBM), the most common primary intracranial malignancy,
is a morphologically diverse neoplasm with dismal prognosis despite multimodality therapy …
is a morphologically diverse neoplasm with dismal prognosis despite multimodality therapy …