Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …

Amorphous solid dispersions (ASDs) are a proven system for achieving a supersaturated
state of drug, in which the concentration of drug is greater than its crystalline solubility. The …

Cervical cancer is known globally as one of the most common health problems in women.
Indeed, one of the most convenient approaches for its treatment is an appropriate …

In recent years, several techniques were employed to develop a local sustained pulmonary
delivery of sildenafil citrate (SC) as an alternative for the intravenous and oral treatment of …

Hot-melt extrusion (HME) technology is one of the primary approaches that has been
implemented in recent years to overcome poor drug solubility/dissolution issues through the …

Solid dispersions (SDs) have emerged as a promising strategy to enhance the solubility and
bioavailability of poorly soluble active pharmaceutical ingredients. However, SDs tend to …

Today, therapeutic candidates with low solubility have become increasingly common in
pharmaceutical research pipelines. Several techniques such as hot melt extrusion, spray …

Both biphasic dissolution and simultaneous dissolution-permeation (DP) systems have great
potential to improve the in vitro-in vivo correlation compared to simple dissolution assays …

Trace levels of peroxides in Plasdone™ S630 grades may cause both degradation and
corresponding decreases in purity levels of drugs sensitive to oxidation. The present study …

Organic solvent-free process or green chemistry is needed for manufacturing
pharmaceutical salts to avoid various environmental, safety, and manufacturing cost issues …