The role of oxidative stress in hyperuricemia and xanthine oxidoreductase (XOR) inhibitors
N Liu, H Xu, Q Sun, X Yu, W Chen… - Oxidative Medicine …, 2021 - Wiley Online Library
Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic
disease caused by the increased formation or reduced excretion of serum uric acid (SUA) …
disease caused by the increased formation or reduced excretion of serum uric acid (SUA) …
[HTML][HTML] Hyperuricemia-related diseases and xanthine oxidoreductase (XOR) inhibitors: an overview
C Chen, JM Lü, Q Yao - Medical science monitor: international …, 2016 - ncbi.nlm.nih.gov
Uric acid is the final oxidation product of purine metabolism in humans. Xanthine
oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric …
oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric …
Past, present and future of xanthine oxidase inhibitors: design strategies, structural and pharmacological insights, patents and clinical trials
Xanthine oxidase, a molybdo-flavoenzyme, and an isoform of xanthine dehydrogenase both
exist as xanthine oxidoreductase and are responsible for purine catabolism. Xanthine …
exist as xanthine oxidoreductase and are responsible for purine catabolism. Xanthine …
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties …
A Šmelcerović, K Tomović, Ž Šmelcerović… - European journal of …, 2017 - Elsevier
Xanthine oxidase (XO), a versatile metalloflavoprotein enzyme, catalyzes the oxidative
hydroxylation of hypoxanthine and xanthine to uric acid in purine catabolism while …
hydroxylation of hypoxanthine and xanthine to uric acid in purine catabolism while …
Toward an understanding of structural insights of xanthine and aldehyde oxidases: an overview of their inhibitors and role in various diseases
Almost all drug molecules become the substrates for oxidoreductase enzymes, get
metabolized into more hydrophilic products and eliminated from the body. These …
metabolized into more hydrophilic products and eliminated from the body. These …
Inhibitors of xanthine oxidase: scaffold diversity and structure‐based drug design
Xanthine oxidase (XO) is the enzyme responsible for the catabolism of purines and their
conversion into uric acid. XO is thus the target for the treatment of hyperuricemia and gout …
conversion into uric acid. XO is thus the target for the treatment of hyperuricemia and gout …
Microwave-assisted multicomponent reactions in heterocyclic chemistry and mechanistic aspects
S Gulati, SE John… - Beilstein Journal of Organic …, 2021 - beilstein-journals.org
Microwave-assisted (MWA) multicomponent reactions (MCRs) have successfully emerged
as one of the useful tools in the synthesis of biologically relevant heterocycles. These …
as one of the useful tools in the synthesis of biologically relevant heterocycles. These …
Xanthine oxidase inhibitors: patent landscape and clinical development (2015–2020)
Introduction Xanthine oxidase (XO) is a molybdoflavoprotein that catalyzes the oxidative
hydroxylation of purines to produce uric acid and reactive oxygen species. These reaction …
hydroxylation of purines to produce uric acid and reactive oxygen species. These reaction …
An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015)
Introduction: Xanthine oxidase (XO) is a versatile molybdoflavoprotein, widely distributed,
occurring in milk, kidney, lung, heart, and vascular endothelium. Catalysis by XO to produce …
occurring in milk, kidney, lung, heart, and vascular endothelium. Catalysis by XO to produce …
Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout
T Nishino, K Okamoto - JBIC Journal of Biological Inorganic Chemistry, 2015 - Springer
Xanthine oxidoreductase (XOR), which is widely distributed from humans to bacteria, has a
key role in purine catabolism, catalyzing two steps of sequential hydroxylation from …
key role in purine catabolism, catalyzing two steps of sequential hydroxylation from …