RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …
investigated as therapeutic targets over the last decades, motivated by their multiple …
Virus–host interactions in foot-and-mouth disease virus infection
K Li, C Wang, F Yang, W Cao, Z Zhu… - Frontiers in …, 2021 - frontiersin.org
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals,
which has been regarded as a persistent challenge for the livestock industry in many …
which has been regarded as a persistent challenge for the livestock industry in many …
The pathogenesis of foot‐and‐mouth disease II: viral pathways in swine, small ruminants, and wildlife; myotropism, chronic syndromes, and molecular virus–host …
J Arzt, B Baxt, MJ Grubman, T Jackson… - Transboundary and …, 2011 - Wiley Online Library
Investigation into the pathogenesis of foot‐and‐mouth disease (FMD) has focused on the
study of the disease in cattle with less emphasis on pigs, small ruminants and …
study of the disease in cattle with less emphasis on pigs, small ruminants and …
Fusion of epithelial cells by Epstein–Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins αvβ6 or αvβ8
LS Chesnokova, SL Nishimura… - Proceedings of the …, 2009 - National Acad Sciences
Epstein–Barr, virus (EBV) is a ubiquitous human herpesvirus that is causally implicated in
the development of lymphoid and epithelial tumors. Entry of virus requires fusion of virus …
the development of lymphoid and epithelial tumors. Entry of virus requires fusion of virus …
Foot-and-mouth disease virus: immunobiology, advances in vaccines and vaccination strategies addressing vaccine failures—an Indian perspective
A mass vaccination campaign in India seeks to control and eventually eradicate foot-and-
mouth disease (FMD). Biosanitary measures along with FMD monitoring are being …
mouth disease (FMD). Biosanitary measures along with FMD monitoring are being …
A Continuous Bovine Kidney Cell Line Constitutively Expressing Bovine αVβ6 Integrin Has Increased Susceptibility to Foot-and-Mouth Disease Virus
Foot-and-mouth disease (FMD) is a worldwide problem limiting the trade of animals and
their products from affected countries. The rapid isolation, seroty**, and vaccine matching …
their products from affected countries. The rapid isolation, seroty**, and vaccine matching …
Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)
Purpose The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis
through activation of transforming growth factor beta (TGFβ). This study sought to quantify …
through activation of transforming growth factor beta (TGFβ). This study sought to quantify …
Targeting of aberrant αvβ6 integrin expression in solid tumors using chimeric antigen receptor-engineered T cells
LM Whilding, AC Parente-Pereira, T Zabinski… - Molecular Therapy, 2017 - cell.com
Expression of the αvβ6 integrin is upregulated in several solid tumors. In contrast,
physiologic expression of this epithelial-specific integrin is restricted to development and …
physiologic expression of this epithelial-specific integrin is restricted to development and …
Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus
Foot-and-mouth disease virus (FMDV) mediates cell entry by attachment to an integrin
receptor, generally αvβ6, via a conserved arginine–glycine–aspartic acid (RGD) motif in the …
receptor, generally αvβ6, via a conserved arginine–glycine–aspartic acid (RGD) motif in the …
Beyond the matrix: the many non-ECM ligands for integrins
B LaFoya, JA Munroe, A Miyamoto… - International journal of …, 2018 - mdpi.com
The traditional view of integrins portrays these highly conserved cell surface receptors as
mediators of cellular attachment to the extracellular matrix (ECM), and to a lesser degree, as …
mediators of cellular attachment to the extracellular matrix (ECM), and to a lesser degree, as …