RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field

BS Ludwig, H Kessler, S Kossatz, U Reuning - Cancers, 2021 - mdpi.com
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Virus–host interactions in foot-and-mouth disease virus infection

K Li, C Wang, F Yang, W Cao, Z Zhu… - Frontiers in …, 2021 - frontiersin.org
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals,
which has been regarded as a persistent challenge for the livestock industry in many …

The pathogenesis of foot‐and‐mouth disease II: viral pathways in swine, small ruminants, and wildlife; myotropism, chronic syndromes, and molecular virus–host …

J Arzt, B Baxt, MJ Grubman, T Jackson… - Transboundary and …, 2011 - Wiley Online Library
Investigation into the pathogenesis of foot‐and‐mouth disease (FMD) has focused on the
study of the disease in cattle with less emphasis on pigs, small ruminants and …

Fusion of epithelial cells by Epstein–Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins αvβ6 or αvβ8

LS Chesnokova, SL Nishimura… - Proceedings of the …, 2009 - National Acad Sciences
Epstein–Barr, virus (EBV) is a ubiquitous human herpesvirus that is causally implicated in
the development of lymphoid and epithelial tumors. Entry of virus requires fusion of virus …

Foot-and-mouth disease virus: immunobiology, advances in vaccines and vaccination strategies addressing vaccine failures—an Indian perspective

RK Singh, GK Sharma, S Mahajan, K Dhama… - Vaccines, 2019 - mdpi.com
A mass vaccination campaign in India seeks to control and eventually eradicate foot-and-
mouth disease (FMD). Biosanitary measures along with FMD monitoring are being …

A Continuous Bovine Kidney Cell Line Constitutively Expressing Bovine αVβ6 Integrin Has Increased Susceptibility to Foot-and-Mouth Disease Virus

M LaRocco, PW Krug, E Kramer, Z Ahmed… - Journal of clinical …, 2013 - Am Soc Microbiol
Foot-and-mouth disease (FMD) is a worldwide problem limiting the trade of animals and
their products from affected countries. The rapid isolation, seroty**, and vaccine matching …

Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)

PT Lukey, C Coello, R Gunn, C Parker… - European Journal of …, 2020 - Springer
Purpose The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis
through activation of transforming growth factor beta (TGFβ). This study sought to quantify …

Targeting of aberrant αvβ6 integrin expression in solid tumors using chimeric antigen receptor-engineered T cells

LM Whilding, AC Parente-Pereira, T Zabinski… - Molecular Therapy, 2017 - cell.com
Expression of the αvβ6 integrin is upregulated in several solid tumors. In contrast,
physiologic expression of this epithelial-specific integrin is restricted to development and …

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

A Kotecha, Q Wang, X Dong, SL Ilca… - Nature …, 2017 - nature.com
Foot-and-mouth disease virus (FMDV) mediates cell entry by attachment to an integrin
receptor, generally αvβ6, via a conserved arginine–glycine–aspartic acid (RGD) motif in the …

Beyond the matrix: the many non-ECM ligands for integrins

B LaFoya, JA Munroe, A Miyamoto… - International journal of …, 2018 - mdpi.com
The traditional view of integrins portrays these highly conserved cell surface receptors as
mediators of cellular attachment to the extracellular matrix (ECM), and to a lesser degree, as …