Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Maintenance of brain function depends on a constant blood supply. Deficits in cerebral
blood flow are linked to cognitive decline, and they have detrimental effects on the outcome …

This e-book will review special features of the cerebral circulation and how they contribute to
the physiology of the brain. It describes structural and functional properties of the cerebral …

The vascular myogenic response refers to the acute reaction of a blood vessel to a change
in transmural pressure. This response is critically important for the development of resting …

1 The regulation of intracellular [Ca2+] in the smooth muscle cells in the wall of small
pressurized cerebral arteries (100‐200 μm) of rat was studied using simultaneous digital …

Ion channels in the plasma membrane of vascular muscle cells that form the walls of
resistance arteries and arterioles play a central role in the regulation of vascular tone …

Ion channels are integral membrane proteins present on the plasma membrane as well as
intracellular membranes. In the human genome, there are more than 400 known genes …

TMEM16A was found recently to be a calcium-activated Cl− channel (CaCC). CaCCs
perform important functions in cell physiology, including regulation of epithelial secretion …

The myogenic response of small arteries and arterioles has been shown to contribute
significantly to autoregulation in different vascular beds. It is characterized by a constriction …