Recent advances in the treatment of Charcot‐Marie‐Tooth neuropathies
Abstract Charcot‐Marie‐Tooth (CMT) neuropathies are one of the most common
neuromuscular disorders. However, despite the identification of more than 100 causative …
neuromuscular disorders. However, despite the identification of more than 100 causative …
HSP70 and HSP90 in neurodegenerative diseases
Molecular chaperones have a role to stabilize proteins or assist them in reaching their native
fold. Heat shock proteins (HSPs) are a family of molecular chaperons that protect proteins …
fold. Heat shock proteins (HSPs) are a family of molecular chaperons that protect proteins …
[HTML][HTML] Mechanisms and treatments in demyelinating CMT
Abstract Demyelinating forms of Charcot-Marie-Tooth disease (CMT) are genetically and
phenotypically heterogeneous and result from highly diverse biological mechanisms …
phenotypically heterogeneous and result from highly diverse biological mechanisms …
Mechanisms and treatment strategies of demyelinating and dysmyelinating Charcot-Marie-Tooth disease
Schwann cells, the myelinating glia of the peripheral nervous system, wrap axons multiple
times to build their myelin sheath. Myelin is of paramount importance for axonal integrity and …
times to build their myelin sheath. Myelin is of paramount importance for axonal integrity and …
Autophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in Charcot-Marie-Tooth type 2 neuropathies
A Sisto, T van Wermeskerken, M Pancher, P Gatto… - Autophagy, 2024 - Taylor & Francis
ABSTRACT HSPB1 [heat shock protein family B (small) member 1] and HSPB8 are essential
molecular chaperones for neuronal proteostasis, as they prevent protein aggregation …
molecular chaperones for neuronal proteostasis, as they prevent protein aggregation …
In silico drug repurposing in multiple sclerosis using scRNA-Seq Data
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system still lacking
a cure. Treatment typically focuses on slowing the progression and managing MS …
a cure. Treatment typically focuses on slowing the progression and managing MS …
[HTML][HTML] Animal models as a tool to design therapeutical strategies for CMT-like hereditary neuropathies
Since ancient times, animal models have provided fundamental information in medical
knowledge. This also applies for discoveries in the field of inherited peripheral neuropathies …
knowledge. This also applies for discoveries in the field of inherited peripheral neuropathies …
[HTML][HTML] Proteostasis plays an important role in demyelinating Charcot Marie Tooth disease
K Libberecht, T Vangansewinkel… - Biochemical …, 2023 - Elsevier
Abstract Type 1 Charcot-Marie-Tooth disease (CMT1) is the most common demyelinating
peripheral neuropathy. Patients suffer from progressive muscle weakness and sensory …
peripheral neuropathy. Patients suffer from progressive muscle weakness and sensory …
Pharmacologic targeting of the C-terminus of heat shock protein 90 improves neuromuscular function in animal models of Charcot Marie Tooth X1 disease
Charcot-Marie-Tooth X1 (CMTX1) disease is an inherited peripheral neuropathy that arises
from loss-of-function mutations in the protein connexin 32 (Cx32). CMTX1 currently lacks a …
from loss-of-function mutations in the protein connexin 32 (Cx32). CMTX1 currently lacks a …
Charcot-Marie-Toots disease: description of 2 clinical cases of the disease in members of the same family (father and daughter)
VS Fedorova, AG Smochilin, AI Kulyakhtin… - The Scientific Notes of …, 2020 - sci-notes.ru
Abstract Charcot—Marie—Tooth disease belongs to a genetically heterogeneous group of
monogenic diseases with a predominant lesion of the peripheral nervous system associated …
monogenic diseases with a predominant lesion of the peripheral nervous system associated …