Pyrin, encoded by the MEFV gene, is an intracellular pattern recognition receptor that
assembles inflammasome complexes in response to pathogen infections. Mutations in the …

The B7 family of co-stimulatory molecules has an important role in driving the activation and
inhibition of immune cells. Evolving data have shown that a related family of molecules—the …

In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells
through an 'inside out'signalling process whereby structurally diverse phosphoantigen (pAg) …

Muscle contraction is initiated by the release of calcium (Ca2+) from the sarcoplasmic
reticulum into the cytoplasm of myocytes through ryanodine receptors (RyRs). RyRs are …

The eukaryotic linear motif (ELM http://elm. eu. org) resource is a hub for collecting,
classifying and curating information about short linear motifs (SLiMs). For> 10 years, this …

RNA helicases and E3 ubiquitin ligases mediate many critical functions in cells, but their
actions have largely been studied in distinct biological contexts. Here, we uncover …

The long-held view that gamma delta (γδ) T cells in mice and humans are fundamentally
dissimilar, as are γδ cells in blood and peripheral tissues, has been challenged by emerging …

Human Vγ9Vδ2 T cells respond to tumor cells by sensing elevated levels of phosphorylated
intermediates of the dysregulated mevalonate pathway, which is translated into activating …

Most human γδ T cells express Vγ2Vδ2 TCRs and play important roles in microbial and
tumor immunity. Vγ2Vδ2 T cells are stimulated by self-and foreign prenyl pyrophosphate …

Abstract Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold
protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins …