Simple Summary Glioblastoma multiforme (GBM) is one of the most aggressive
malignancies, accounting for 14.5% of all central nervous system tumors and 48.6% of …

Telomeres maintain genomic integrity in normal cells, and their progressive shortening
during successive cell divisions induces chromosomal instability. In the large majority of …

Background The prediction of clinical behavior, response to therapy, and outcome of
infiltrative glioma is challenging. On the basis of previous studies of tumor biology, we …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

Telomeres are located at the ends of chromosomes and protect them from degradation.
Suppressing the activity of telomerase, a telomere-synthesizing enzyme, and maintaining …

Bladder cancer (BC) ranks as the sixth most prevalent cancer in the world, with a steady rise
in its incidence and prevalence, and is accompanied by a high morbidity and mortality. BC is …

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors,
encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential) …

The tumor microenvironment (TME) demonstrates distinct hallmarks, including acidosis,
hypoxia, reactive oxygen species (ROS) generation, and altered ion fluxes, which are crucial …

Mutations in the promoter of human telomerase reverse transcriptase (hTERT) result in
hyperactivation of hTERT. Notably, all mutations are G> A transitions, frequently found in a …