Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …

Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA (α-amino-3-
hydroxyl-5-methyl-4-isoxazolepropionate) receptors on cerebellar granule cells. Stargazin …

Functional expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors in cerebellar granule cells requires stargazin, a member of a large family of four …

Abstract AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors mediate
fast excitatory synaptic transmission in the brain. These ion channels rapidly deactivate and …

The zebrafish is a leading model for studies of vertebrate development and genetics. Its
embryonic motor behaviors are easy to assess (eg for mutagenic screens), the embryos …

Glutamate receptors of the AMPA-subtype (AMPARs), together with the transmembrane
AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the …

Synaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA-
type glutamate receptors at excitatory synapses; however, the crucial phosphorylated …

Glutamate, the major excitatory neurotransmitter in the brain, acts primarily on two types of
ionotropic receptors: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) …

The cerebellum and its associated circuitry constitutes the entire essential neuronal system
for classical conditioning of eye-blink and other discrete responses (eg limb flexion) learned …