The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …

Definition Apoptosis, programmed cell death, has a central role in developmental biology
and in maintaining the equilibrium of renewing tissues. A founding member of the Bcl-2 …

Heat shock proteins (HSPs) play cytoprotective activities under pathological conditions
through the initiation of protein folding, repair, refolding of misfolded peptides, and possible …

Obtaining complete protein inventories for subcellular regions is a challenge that often limits
our understanding of cellular function, especially for regions that are impossible to purify and …

A simple genetic strategy involving loxP-flanked alleles encoding CPT2 (Cpt2fl/fl) has
provided the means with which to disrupt FAO within specific mouse cell types6. This is …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

In healthy cells, cytochrome c (Cyt c) is located in the mitochondrial intermembrane/
intercristae spaces, where it functions as an electron shuttle in the respiratory chain and …

Mitochondria play a major role in apoptosis triggered by many stimuli. They integrate death
signals through Bcl-2 family members and coordinate caspase activation through the …

Mutations in PTEN-induced kinase 1 (PINK1) cause early onset autosomal recessive
Parkinson's disease (PD). PINK1 is a 63 kDa protein kinase, which exerts a neuroprotective …